Document Detail

High-altitude retinopathy.
MedLine Citation:
PMID:  7452886     Owner:  NLM     Status:  MEDLINE    
Thirty-nine healthy subjects were examined before and after a stay at 5,360 m by ophthalmoscopy and by retinal photography. Twenty of them were also tested for visual acuity, scotomata, and capillary leakage. Vascular engorgement and tortuosity and disc hyperemia were seen in all subjects at altitude and are a "normal" response to hypoxia. Twenty-two (56%) of the subjects had retinal hemorrhages and one showed "cotton-wool spots". These changes are abnormal reactions and are considered high-altitude retinopathy. After maximal exertion on a cycle ergometer, fresh hemorrhages were observed in seven of 34 subjects. The incidence of hemorrhage associated with exercise was significantly greater than predicted. Fluorescein leakage was noted after exercise in eight of 20 persons tested and was associated with exercise-induced hemorrhages. Two persons developed premacular hemorrhages.
D M McFadden; C S Houston; J R Sutton; A C Powles; G W Gray; R S Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  245     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  581-6     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / complications
Atmospheric Pressure
Capillary Resistance
Informed Consent
Oxygen / blood
Physical Exertion
Retinal Diseases / etiology*
Retinal Hemorrhage / etiology
Grant Support
Reg. No./Substance:

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