Document Detail


High altitude residence during pregnancy alters cytokine and catecholamine levels.
MedLine Citation:
PMID:  12516658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed the impact of high altitude residence during pregnancy on parameters of maternal immune and endocrine system function. Urinary catecholamines, and serum cytokines, estriol, and cortisol were assessed during pregnancy in women living at moderate or high altitude. Women residing at high altitude exhibited elevated levels of proinflammatory cytokines only during pregnancy, and tended to have higher levels of catecholamines during pregnancy than women living at lower altitude. These data suggest that the combination of high altitude and pregnancy alters the maternal neural-immune axis in a manner that may predispose women to suboptimal birth outcomes.
Authors:
Mary E Coussons-Read; Robert S Mazzeo; Margaret H Whitford; Mischel Schmitt; Lorna G Moore; Stacy Zamudio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  48     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-08     Completed Date:  2003-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  344-54     Citation Subset:  IM    
Affiliation:
Department of Psychology and Program in Health and Behavioral Sciences, University of Colorado at Denver, Denver, CO 80217, USA. mary.coussons-read@cudenver.edu
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MeSH Terms
Descriptor/Qualifier:
Altitude*
Catecholamines / urine*
Cytokines / blood*
Estradiol / blood
Female
Humans
Hydrocortisone / blood
Pregnancy / immunology*,  metabolism*
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Cytokines; 50-23-7/Hydrocortisone; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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