Document Detail

High-altitude pulmonary hypertension: effects of captopril on pulmonary and systemic arterial pressures.
MedLine Citation:
PMID:  8872846     Owner:  NLM     Status:  MEDLINE    
The purpose of investigation was the assessment of the effect of captopril on both systemic (Pa) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44 +/- 6.8 years) with HAPH and mild-to-moderate systemic arterial hypertension were included in the study. All the patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst), mean PPA (PPA) and diastolic PPA (PPA,diast). After a 4 week placebo phase, patients with PPA,syst > 25 mm Hg, PPA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) > 100 mm Hg received captopril (50-75 mg at 08.00) for a period of 12 weeks. The statistical evaluation of the results were made using the Student's t-test. It was found that captopril significantly decreases PPA and Pa.
Z A Niazova; T A Batyraliev; K S Aikimbaev; G Z Kudaiberdieva; F Akgul; Y K Soodanbekova; A Birand
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  10 Suppl 3     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S141-2     Citation Subset:  IM    
Cukurova University, Balcali Hospital, Department of Cardiology, Adana, Turkey.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Captopril / therapeutic use*
Hypertension, Pulmonary / drug therapy*,  etiology*,  physiopathology
Middle Aged
Pulmonary Circulation / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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