Document Detail


High-altitude pulmonary hypertension: effects of captopril on pulmonary and systemic arterial pressures.
MedLine Citation:
PMID:  8872846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of investigation was the assessment of the effect of captopril on both systemic (Pa) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44 +/- 6.8 years) with HAPH and mild-to-moderate systemic arterial hypertension were included in the study. All the patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst), mean PPA (PPA) and diastolic PPA (PPA,diast). After a 4 week placebo phase, patients with PPA,syst > 25 mm Hg, PPA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) > 100 mm Hg received captopril (50-75 mg at 08.00) for a period of 12 weeks. The statistical evaluation of the results were made using the Student's t-test. It was found that captopril significantly decreases PPA and Pa.
Authors:
Z A Niazova; T A Batyraliev; K S Aikimbaev; G Z Kudaiberdieva; F Akgul; Y K Soodanbekova; A Birand
Related Documents :
12162936 - Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in atheroscl...
2441196 - Haemodynamic effects of captopril in acute left ventricular failure complicating myocar...
9406146 - An overview of the influence of ace inhibitors on fetal-placental circulation and perin...
3330936 - Autoregulation of glomerular blood flow during converting-enzyme inhibition by captopril.
20595676 - Increased fructose associates with elevated blood pressure.
6485736 - Reaction time course during weaning from respirator treatment.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  10 Suppl 3     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S141-2     Citation Subset:  IM    
Affiliation:
Cukurova University, Balcali Hospital, Department of Cardiology, Adana, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Altitude*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Captopril / therapeutic use*
Humans
Hypertension, Pulmonary / drug therapy*,  etiology*,  physiopathology
Middle Aged
Pulmonary Circulation / drug effects*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Repeated fasting and refeeding with 20:5, n-3 eicosapentaenoic acid (EPA): a novel approach for rapi...
Next Document:  Efficacy of different antihypertensive drugs in the emergency department.