Document Detail

High altitude pulmonary edema, down syndrome, and obstructive sleep apneas.
MedLine Citation:
PMID:  18578649     Owner:  NLM     Status:  MEDLINE    
A 24-year-old adult with a Down syndrome was admitted in December 2006 at the Moutiers hospital in the French Alps for an acute inaugural episode of high altitude pulmonary edema (HAPE) that occurred in the early morning of day 3 after his arrival to La Plagne (2000 m). This patient presented an interventricular septal defect operated on at the age of 7, a hypothyroidism controlled by 50 microg levothyrox, a state of obesity (BMI 37.8 kg/m(2)), and obstructive sleep apneas with a mean of 42 obstructive apneas or hypopneas per hour, treated with continuous positive airway pressure (CPAP). The patient refused to use his CPAP during his stay in La Plagne. At echocardiography, resting parameters were normal, with a left ventricular, ejection fraction of 60%, a normokinetic right ventricle, and an estimated systolic pulmonary artery pressure (sPAP) of 30 mmHg. At exercise, sPAP rose to 45 mmHg and the right ventricle was still normokinetic and not dilated. An exercise hypoxic tolerance test performed at 60 W and at the equivalent altitude of 3300 m revealed a severe drop in arterial oxygen saturation down to 60%, with an abnormal low ventilatory response to hypoxia, suggesting a defect in peripheral chemosensitivity to hypoxia. In conclusion, patients with Down syndrome, including adults with no cardiac dysfunction and regular physical activity, are at risk of HAPE even at moderate altitude when they suffer from obstructive sleep apneas associated with obesity and low chemoresponsiveness. This observation might be of importance since an increasing number of young adults with Down syndrome participate in recreational or sport activities, including skiing and mountaineering.
Jean-Paul Richalet; Cécile Chenivesse; Philippe Larmignat; Laurent Meille
Related Documents :
24433239 - Maternal obesity and the developmental programming of hypertension: a role for leptin.
6810869 - Investigation of the combined effects of bedrest and mild hypoxia.
8167289 - The use of dichloroacetate in the treatment of overwhelming hypoxic acidosis.
4629439 - Potentiation of the contractile effects of norepinephrine by hypoxia.
6323659 - The effects of hypobaric hypoxia on the corticotroph population of the adenohypophysis ...
1600639 - Hypoxic attenuation of brain stem serotonin does not influence sodium-induced hypertens...
9433699 - Retrospective evaluation of cardiopulmonary and acid-base variables during long-term ba...
23817839 - Anti-hypertensive treatment in pheochromocytoma and paraganglioma: current management a...
16205919 - Lateral pressure profiles in cholesterol-dppc bilayers.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  9     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-81     Citation Subset:  IM; S    
AP-HP, hôpital Avicenne, Service de physiologie, explorations fonctionnelles et médecine du sport and Département d'anesthésie et réanimation, Bobigny, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Altitude Sickness / diagnosis*,  etiology
Down Syndrome / complications*
Pulmonary Circulation
Pulmonary Edema / diagnosis*,  etiology
Sleep Apnea, Obstructive / complications*
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Q...
Next Document:  Third place: Flank position is associated with higher skin-to-surface interface pressures in men ver...