Document Detail

High activity of fatty acid oxidation enzymes in human placenta: implications for fetal-maternal disease.
MedLine Citation:
PMID:  12971426     Owner:  NLM     Status:  MEDLINE    
As the human fetus and placenta are considered to be primarily dependent on glucose oxidation for energy metabolism, the cause of the remarkable association between severe maternal pregnancy complications and the carriage of a fetus with an inborn error of mitochondrial long-chain fatty acid oxidation (FAO) has remained obscure. We analysed human term placenta and chorionic villus samples for the activities of a variety of enzymes involved in FAO, and compared the results with those obtained in human liver. All enzymes were found to be expressed, with a very high activity of two enzymes involved in the metabolism of long-chain fatty acids (CPT2 and VLCAD), whereas the activity of medium-chain acyl-CoA dehydrogenase (MCAD) was found to be low, when compared to liver. These results suggest that fatty acid oxidation may play an important role in energy generation in human placenta, and that a deficiency in the placental oxidation of long-chain FAO may result in placental dysfunction, thus causing gestational complications.
N A Oey; M E J den Boer; J P N Ruiter; R J A Wanders; M Duran; H R Waterham; K Boer; J A M van der Post; F A Wijburg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of inherited metabolic disease     Volume:  26     ISSN:  0141-8955     ISO Abbreviation:  J. Inherit. Metab. Dis.     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-15     Completed Date:  2004-04-01     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  7910918     Medline TA:  J Inherit Metab Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
Department of Paediatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Acyl-CoA Dehydrogenase / chemistry*,  metabolism*
Carnitine O-Palmitoyltransferase / metabolism*
Chorionic Villi / enzymology
Fatty Acids / metabolism*
Liver / enzymology
Placenta / enzymology*
Pregnancy Complications / etiology
Reg. No./Substance:
0/Fatty Acids; EC Dehydrogenase; EC O-Palmitoyltransferase

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