| High accumulation of 2-deoxy-2-fluorine-18-fluoro-D-galactose by well-differentiated hepatomas of mice and rats. | |
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MedLine Citation:
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PMID: 8478711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potential application of 2-deoxy-2-[18F]fluoro-D-galactose for the detection and evaluation of hepatomas with PET was examined in mouse and rat liver tumor models. Biodistribution studies showed that uptake of this marker was high in well-differentiated, spontaneous hepatoma of C3H mice at almost 92% of the normal liver level. The uptake by well-differentiated Morris rat hepatoma (5123D) was relatively high and second to that of the C3H hepatoma. On the other hand, uptake values for poorly differentiated mouse hepatoma (MH129P), rat hepatomas (AH109A, AH272), mouse melanoma (B-16) and mammary carcinoma (FM3A) were very low and only 14%-18% of that in the normal liver. The results suggest that while well-differentiated hepatomas maintain a high galactose metabolic activity, poorly differentiated hepatomas or other tumors lose this to a large extent. Consequently, this radiopharmaceutical can be used with PET for biochemical characterization of hepatomas and the differential diagnosis between hepatomas and other cancers. |
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Authors:
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H Fukuda; J Takahashi; T Fujiwara; K Yamaguchi; Y Abe; K Kubota; T Sato; H Miyazawa; J Hatazawa; M Tada |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 34 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-05-27 Completed Date: 1993-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 780-6 Citation Subset: IM |
Affiliation:
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Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fluorine Radioisotopes / diagnostic use Fucose / analogs & derivatives*, diagnostic use, pharmacokinetics Liver Neoplasms, Experimental / metabolism*, radionuclide imaging Mice Mice, Inbred C3H Rats Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 3713-31-3/Fucose; 51146-53-3/2-deoxy-2-fluorogalactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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