Document Detail

High White Matter Lesion Load Is Associated with Hippocampal Atrophy in Mild Cognitive Impairment.
MedLine Citation:
PMID:  21293123     Owner:  NLM     Status:  Publisher    
Background: Mild cognitive impairment (MCI) is a heterogeneous condition suggested as a prodromal state of Alzheimer's disease (AD) and subcortical vascular dementia (SVD). Recent findings suggest that white matter lesions (WML) may be associated with hippocampal atrophy. The objective of the study was to examine hippocampal and WML volumes in MCI patients and to examine if WML were linked to hippocampal atrophy. Methods: The Gothenburg MCI study is a clinically based longitudinal study with biennial clinical assessments. The participants (n = 166) consist of 92 patients with stable MCI, 30 patients with converting MCI, and 44 healthy controls. WML volumes was measured manually using MRIcron. Automated segmentation of hippocampal and total white matter volumes was performed using FreeSurfer. Results: The patients converting from MCI to dementia had reduced hippocampal volume. Stable MCI patients had fewer WML and converting MCI patients had more WML compared to controls. Hippocampal volume was only correlated to WML volume (ρ = 0.57; p < 0.01) in the quartile (n = 42) with the most WML. Conclusions: Hippocampal atrophy is present in both AD and SVD. Hippocampal volume was associated with WML volume only in the high WML quartile, suggesting that the WML volume must reach a threshold before hippocampal atrophy is seen.
C Eckerström; E Olsson; N Klasson; M Bjerke; M Göthlin; M Jonsson; S Rolstad; H Malmgren; A Wallin; A Edman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-03
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  31     ISSN:  1421-9824     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  132-138     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
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