Document Detail

High urinary sodium is associated with increased carotid intima-media thickness in normotensive overweight and obese adults.
MedLine Citation:
PMID:  20508622     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increased dietary sodium has been reported to increase cardiovascular disease (CVD) risk, perhaps through blood pressure (BP)-independent vascular remodeling. Carotid intima-media thickness (IMT) is an accepted measure of structural vascular remodeling and a strong predictor of CVD. This study aimed to determine whether urinary sodium is positively associated with carotid IMT in normotensive overweight and obese adults.
METHODS: We evaluated baseline data from 258 participants in the Slow Adverse Vascular Effects (SAVE) clinical trial. Urinary sodium was measured from one 24-h urine collection from each individual. Carotid IMT was measured using high-resolution B-mode ultrasonography. Participants were categorized into quartiles of urinary sodium.
RESULTS: There was a significant positive trend with greater IMT associated with increasing urinary sodium quartile in univariate linear regression (P = 0.047). This trend was significant when adjusting for age, sex, race, and systolic BP (SBP) (P = 0.03) as well as in a fully adjusted model (P = 0.04). In pairwise comparisons, the highest urinary sodium quartile had a significantly greater mean IMT (0.62 mm) than the lowest urinary sodium quartile (0.59 mm) after adjustment for age, sex, race, and SBP (P = 0.04). This comparison lost significance after the addition of BMI.
CONCLUSIONS: In our community-based sample of normotensive overweight and obese adults, we observed a significant positive trend in carotid IMT with increasing quartile of urinary sodium. If the ongoing clinical trial confirms this relationship between sodium and carotid IMT, it would lend support to efforts to decrease sodium intake in overweight and obese individuals.
Jennifer N Njoroge; Samar R El Khoudary; Linda F Fried; Emma Barinas-Mitchell; Kim Sutton-Tyrrell
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-05-27
Journal Detail:
Title:  American journal of hypertension     Volume:  24     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-17     Completed Date:  2011-02-11     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
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MeSH Terms
Body Mass Index
Carotid Arteries / pathology*
Cross-Sectional Studies
Middle Aged
Obesity / pathology*,  urine
Overweight / pathology*,  urine
Sodium / blood,  urine*
Sodium, Dietary / adverse effects
Tunica Intima / pathology*
Tunica Media / pathology*
Grant Support
R01 HL077525/HL/NHLBI NIH HHS; R01 HL077525-01A2/HL/NHLBI NIH HHS; R01 HL077525-01A2/HL/NHLBI NIH HHS; R01 HL077525-02/HL/NHLBI NIH HHS; R01 HL077525-03/HL/NHLBI NIH HHS; R01 HL077525-04/HL/NHLBI NIH HHS; T32 HL083825/HL/NHLBI NIH HHS; T32 HL083825-01/HL/NHLBI NIH HHS; T32 HL083825-01A2/HL/NHLBI NIH HHS; T32 HL083825-02/HL/NHLBI NIH HHS; T32 HL083825-03/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Sodium, Dietary; 9NEZ333N27/Sodium

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