Document Detail

High uric acid level during the first 20 weeks of pregnancy is associated with higher risk for gestational diabetes mellitus and mild preeclampsia.
MedLine Citation:
PMID:  20822424     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between uric acid (UA) level during the first 20 weeks of pregnancy and the development of gestational diabetes mellitus (GDM) and preeclampsia in the second half of pregnancy.
METHODS: The study population included registered births (n = 5507) between 2001 and 2007 in a tertiary medical center. The UA levels during the first 20 weeks of pregnancy were sorted by UA ≤ 2.4 mEq/L; UA = 2.5-4.0 mEq/L, UA = 4.1-5.5 mEq/L, and UA > 5.5 mEq/L. The linear-by-linear chi-square test and ROC curves were used to determine the association between UA level during the first 20 weeks and pregnancy complications. Multivariate analyses were performed to demonstrate whether UA level is an independent factor for the prevalence of preeclampsia and GDM.
RESULTS: Significant linear association was documented between UA level in the first 20 weeks and the prevalence of GDM and mild preeclampsia. The lowest and the highest prevalence of GDM were found in the UA ≤ 2.4 mEq/L group (6.3%) and in the UA > 5.5 mEq/L group (10.5%) (p < 0.001), respectively. Mild preeclampsia was diagnosed in 2.1% of the patients from the UA ≤ 2.4 mEq/L group, 3.3% from the UA = 2.5-4.0 mEq/L group, 5.3% from the UA = 4.1-5.5 mEq/L group, and 4.5% from the UA > 5.5 mEq/L group (p < 0.001). Three multiple logistic regression models controlling for maternal age showed that UA level is an independent risk factor for both GDM and mild preeclampsia.
CONCLUSIONS: UA levels in the highest quartile of the normal range during the first 20 weeks of pregnancy are associated with higher risk for the development of GDM and mild preeclampsia.
Talya Wolak; Ruslan Sergienko; Arnon Wiznitzer; Esther Paran; Eyal Sheiner
Related Documents :
22535344 - [cervical incompetence: diagnosis, indications and cerclage outcome].
8033524 - Increases in serum lipids during pregnancy in type 1 diabetic women with nephropathy.
2262874 - Early prediction of fetal macrosomia in diabetes mellitus.
6742044 - Obstetric management when normoglycemia is maintained in diabetic pregnant women with v...
12956694 - Linear polarized infrared irradiation using super lizer is an effective treatment for m...
24689854 - Treatment with ecg decreases the vascular density and increases the glandular density o...
Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  31     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-22     Completed Date:  2012-11-01     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-15     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Diabetes, Gestational / blood*
Multivariate Analysis
Pre-Eclampsia / blood*
Pregnancy Trimester, First / blood
ROC Curve
Retrospective Studies
Risk Assessment
Uric Acid / blood*
Young Adult
Reg. No./Substance:
0/Biological Markers; 268B43MJ25/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biological activity of the Agrobacterium rhizogenes-derived trolC gene of Nicotiana tabacum and its ...
Next Document:  HELLP syndrome: 8 years of experience from a tertiary referral center in western Turkey.