Document Detail


High times, low sats: diffuse pulmonary infiltrates associated with chronic synthetic cannabinoid use.
MedLine Citation:
PMID:  23539384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: In recent years, cases of severe adverse effects from recreational use of synthetic cannabinoids (SC) have established that these agents represent a novel toxicologic hazard.
CASE REPORT: A 21-year-old male presenting as a vehicular trauma victim was noted with diffuse pulmonary infiltrates related to chronic inhalation of multiple synthetic cannabinoid-containing products. Chest imaging revealed bilateral, subacute lung infiltrates; histopathological analysis of bronchial and alveolar tissues revealed an inflammatory process. An extensive workup failed to identify infectious, malignant, autoimmune, or hematologic causes of the syndrome, and toxicological analysis of the blood and body fluids confirmed the presence of multiple synthetic cannabinoids and metabolites. The patient recovered after an 8-day ICU course, wherein he received antibiotics, steroids, and mechanical ventilation.
DISCUSSION: This case contributes to the currently evolving knowledge about SC agents, adding a rarely described pulmonary complication to the growing list of adverse effects associated with these products.
Authors:
Sameir Alhadi; Anupama Tiwari; Rais Vohra; Roy Gerona; Janak Acharya; Kathryn Bilello
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of medical toxicology : official journal of the American College of Medical Toxicology     Volume:  9     ISSN:  1937-6995     ISO Abbreviation:  J Med Toxicol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-20     Completed Date:  2013-12-17     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101284598     Medline TA:  J Med Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Accidents, Traffic
Administration, Inhalation
Adult
Cannabinoids / administration & dosage,  metabolism,  pharmacokinetics,  toxicity*
Designer Drugs / administration & dosage,  metabolism,  pharmacokinetics,  toxicity*
Humans
Leukocytosis / etiology
Lung / drug effects*,  immunology
Male
Pneumonia / etiology*,  therapy
Psychotropic Drugs / administration & dosage,  metabolism,  pharmacokinetics,  toxicity*
Substance-Related Disorders / complications,  immunology,  metabolism,  physiopathology*
Syncope / etiology
Treatment Outcome
Wounds and Injuries / complications,  therapy
Young Adult
Chemical
Reg. No./Substance:
0/Cannabinoids; 0/Designer Drugs; 0/Psychotropic Drugs
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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