Document Detail


High throughput bioassays using nanoparticles.
MedLine Citation:
PMID:  20156145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An overview of the usefulness of different nanoparticles to improve the features of high throughput separation and individual and multiplexed detection bioassays is presented. Although the development of microarray and microfluidic systems has expanded the capabilities of these high throughput assays, the combined use of NPs and these devices has provided them with new applications in drug discovery, proteomic and genomic studies, and clinical diagnosis. This article reviews the wide application field of magnetic, gold, silver, semiconductor and other nanoparticles in high throughput bioassays. Also, the versatility of the detection systems described shows that NPs are useful alternatives to fluorescent dyes, which are often used in these assays.
Authors:
Agustina Gómez-Hens; Juan M Fernández-Romero; Maria P Aguilar-Caballos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Combinatorial chemistry & high throughput screening     Volume:  13     ISSN:  1875-5402     ISO Abbreviation:  Comb. Chem. High Throughput Screen.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810948     Medline TA:  Comb Chem High Throughput Screen     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  309-17     Citation Subset:  IM    
Affiliation:
Department of Analytical Chemistry, Marie Curie Annex Building, Campus of Rabanales, University of Córdoba, E-14071 Córdoba, Spain. qa1gohea@uco.es
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MeSH Terms
Descriptor/Qualifier:
Biological Assay / methods*
Limit of Detection
Nanoparticles*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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