| High Serum IL-21 Levels after 12 Weeks of Antiviral Therapy Predict HBeAg Seroconversion in Chronic Hepatitis B. | |
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MedLine Citation:
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PMID: 22173154 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Interleukin-21 (IL-21) stimulates T cell and B cell responses and plays a role in control of chronic viral infections. The role of IL-21 in chronic hepatitis B virus (HBV) infection is not understood. METHODS: Serum IL-21 levels were measured by enzyme immunoassay in 75 HBeAg-positive chronic hepatitis B (CHB) patients undergoing Telbivudine treatment. The findings were validated in 103 patients from a separate clinical trial of Telbivudine. A complete response to Telbivudine was defined as having both HBeAg seroconversion and serum HBV-DNA level < 300 copies/ml by treatment week 52. The proportions of T-cells producing IL-21 and/or expressing programmed death 1 (PD-1) in peripheral blood mononuclear cells were assessed longitudinally during treatment by intracellular cytokine staining and flow cytometry. RESULTS: Median serum IL-21 levels at treatment week 12 were significantly higher in patients who did achieve versus patients who did not achieve a complete response in both the initial (128.4 vs. 69.2 pg/ml, p=0.003) and the validation (142.2 vs. 89.9 pg/ml, p=0.004) trials. Serum levels of IL-21 (p=0.005) or HBV-DNA (p=0.003) levels at treatment week 12 independently predicted HBeAg seroconversion in the first year of treatment. The decrease in PD-1 expression on CD4(+) and CD8(+) T cells during the first 12 weeks on Telbivudine treatment were not correlated with changes in IL-21 concentrations. CONCLUSIONS: Serum IL-21 levels may be a biomarker for HBeAg seroconversion, and may contribute to individualisation of antiviral therapy in HBeAg-positive CHB. IL-21 may also have a role in immunotherapy for CHB. |
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Authors:
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Shi-Wu Ma; Xuan Huang; Yong-Yin Li; Li-Bo Tang; Xiao-Feng Sun; Xiao-Tao Jiang; Yue-Xin Zhang; Sun Jian; Zhi-Hua Liu; William G H Abbott; Yu-Hong Dong; Nikolai V Naoumov; Jin-Lin Hou |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
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Title: Journal of hepatology Volume: - ISSN: 0168-8278 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Hepatology Unit and Key Lab for Organ Failure Research, Nanfang Hospital, Southern Medical University, No.1838, North Guangzhou Avenue, Guangzhou, 510515, China; Department of Infectious Diseases, Kunming General Hospital of PLA, Kunming, 650032, China. |
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