Document Detail


High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.
MedLine Citation:
PMID:  19447929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in patients with early-stage rheumatoid arthritis (RA) in relation to other serologic variables and magnetic resonance imaging (MRI) features. METHODS: Ninety-eight patients with early-stage RA, whose disease duration from onset was less than 2 years, were enrolled. The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. The MRI features included the number of sites scored positive for synovitis, bone edema, and bone erosion. RESULTS: Serum COMP concentration was not different among groups identified with low, moderate, and high DAS28-CRP values. However, COMP values were statistically high in subjects positive for bone erosions on MRI compared with the subjects who were negative for bone erosions. A positive correlation of COMP with CRP and with MMP-3 values was also identified. CONCLUSION: Elevation of COMP may reflect joint damage that is dependent on the synovial inflammatory process in early-stage RA.
Authors:
Keita Fujikawa; Atsushi Kawakami; Mami Tamai; Masataka Uetani; Shoichiro Takao; Kazuhiko Arima; Naoki Iwamoto; Toshiyuki Aramaki; Shinya Kawashiri; Kunihiro Ichinose; Makoto Kamachi; Hideki Nakamura; Tomoki Origuchi; Hiroaki Ida; Kiyoshi Aoyagi; Katsumi Eguchi
Related Documents :
22691639 - Biologically enhanced healing of the rotator cuff.
16621619 - Preliminary study on diffraction enhanced radiographic imaging for a canine model of ca...
8205939 - Magnetic resonance imaging in children receiving quinolones: no evidence of quinolone-i...
15311729 - Computerised tomography vs. pathological staging of laryngeal cancer: a 6-year complete...
22797659 - Mr imaging of the placenta: what a radiologist should know.
11044029 - Osteochondritis dissecans of the tibial plafond: imaging characteristics and a review o...
25225119 - Structural, phenotypic and functional maturation of bone marrow dendritic cells (bmdcs)...
10899419 - Case report: the "yin-yang" sign-seen with spiral computed tomography for pulmonary emb...
12105799 - Ct and mr in pulmonary embolism: a changing role for nuclear medicine in diagnostic str...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  36     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1126-9     Citation Subset:  IM    
Affiliation:
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Arthritis, Rheumatoid / blood*,  pathology,  physiopathology
Biological Markers / blood
Bone and Bones / pathology*
C-Reactive Protein / analysis*
Extracellular Matrix Proteins / blood*
Female
Glycoproteins / blood*
Health Status
Humans
Joints / pathology
Magnetic Resonance Imaging / methods*
Male
Matrix Metalloproteinase 3 / blood*
Middle Aged
Severity of Illness Index
Synovitis / pathology
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/cartilage matrix protein; 9007-41-4/C-Reactive Protein; EC 3.4.24.17/Matrix Metalloproteinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High frequency of cephalic neural crest cells shows coexistence of neurogenic, melanogenic, and oste...
Next Document:  Relationship Between Pack-year History of Smoking and Response to Tumor Necrosis Factor Antagonists ...