Document Detail

High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.
MedLine Citation:
PMID:  19447929     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in patients with early-stage rheumatoid arthritis (RA) in relation to other serologic variables and magnetic resonance imaging (MRI) features. METHODS: Ninety-eight patients with early-stage RA, whose disease duration from onset was less than 2 years, were enrolled. The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. The MRI features included the number of sites scored positive for synovitis, bone edema, and bone erosion. RESULTS: Serum COMP concentration was not different among groups identified with low, moderate, and high DAS28-CRP values. However, COMP values were statistically high in subjects positive for bone erosions on MRI compared with the subjects who were negative for bone erosions. A positive correlation of COMP with CRP and with MMP-3 values was also identified. CONCLUSION: Elevation of COMP may reflect joint damage that is dependent on the synovial inflammatory process in early-stage RA.
Keita Fujikawa; Atsushi Kawakami; Mami Tamai; Masataka Uetani; Shoichiro Takao; Kazuhiko Arima; Naoki Iwamoto; Toshiyuki Aramaki; Shinya Kawashiri; Kunihiro Ichinose; Makoto Kamachi; Hideki Nakamura; Tomoki Origuchi; Hiroaki Ida; Kiyoshi Aoyagi; Katsumi Eguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  36     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1126-9     Citation Subset:  IM    
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
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MeSH Terms
Aged, 80 and over
Arthritis, Rheumatoid / blood*,  pathology,  physiopathology
Biological Markers / blood
Bone and Bones / pathology*
C-Reactive Protein / analysis*
Extracellular Matrix Proteins / blood*
Glycoproteins / blood*
Health Status
Joints / pathology
Magnetic Resonance Imaging / methods*
Matrix Metalloproteinase 3 / blood*
Middle Aged
Severity of Illness Index
Synovitis / pathology
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/cartilage matrix protein; 9007-41-4/C-Reactive Protein; EC Metalloproteinase 3

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