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High-Resolution Versus Standard-Resolution Cardiovascular Magnetic Resonance Myocardial Perfusion Imaging for the Detection of Coronary Artery Disease.
MedLine Citation:
PMID:  22499848     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Although accelerated high-spatial-resolution perfusion-CMR has been shown to be clinically feasible, there has not yet been a direct comparison with standard-resolution methods. We hypothesised that higher spatial resolution detects more subendocardial ischemia and leads to greater diagnostic accuracy for the detection CAD. This study compared the diagnostic accuracy of high-resolution and standard-resolution cardiovascular magnetic resonance (CMR) myocardial perfusion imaging in patients with suspected coronary artery disease (CAD). METHODS AND RESULTS: -One-hundred and eleven patients were recruited to undergo two separate perfusion-CMR studies at 1.5-T, one with standard-resolution (2.5x2.5mm in-plane) and one with high-resolution (1.6x1.6mm in-plane) acquisition. High-resolution acquisition was facilitated by eight-fold k-t broad linear speed up technique (BLAST) acceleration. Two observers visually graded perfusion in each myocardial segment on a 4-point scale. Segmental scores were summed to produce a perfusion score for each patient. All patients underwent invasive coronary angiography and CAD was defined as stenosis ≥ 50% luminal diameter (quantitative coronary angiography). CMR data were successfully obtained in 100 patients. In patients with CAD (n=70), more segments were determined to have subendocardial ischemia with high-resolution than with standard-resolution acquisition (279 vs.108; p<0.001). High-resolution acquisition had a greater diagnostic accuracy than standard-resolution for identifying single-vessel disease (area under the curve [AUC]: 0.88 vs. 0.73; p<0.001) or multi-vessel disease (AUC: 0.98 vs. 0.91; p=0.002) and overall (AUC: 0.93 vs. 0.83; p<0.001). CONCLUSIONS: -High-resolution perfusion-CMR has greater overall diagnostic accuracy than standard-resolution acquisition for the detection of CAD in both single and multi-vessel disease and detects more subendocardial ischemia.
Authors:
Manish Motwani; Neil Maredia; Timothy A Fairbairn; Sebastian Kozerke; Aleksandra Radjenovic; John P Greenwood; Sven Plein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-12
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 University of Leeds, Leeds, UK;
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