Document Detail


High-resolution manometry of pharyngeal swallow pressure events associated with effortful swallow and the Mendelsohn maneuver.
MedLine Citation:
PMID:  22215280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effortful swallow and the Mendelsohn maneuver are two common strategies to improve disordered swallowing. We used high-resolution manometry (HRM) to quantify the effects of these maneuvers on pressure and timing characteristics. Fourteen normal subjects swallowed multiple, 5-ml water boluses using three techniques: normal swallow, effortful swallow, and the Mendelsohn maneuver. Maximum pressure, rate, duration, area integral, and line integral were determined for the velopharynx and tongue base. Minimum pressure, duration of pressure-related change, duration of nadir pressure, maximum preopening and postclosure pressure, area integral, and line integral were recorded for the upper esophageal sphincter (UES). Area and line integrals of the velopharyngeal pressure curve significantly increased with the Mendelsohn maneuver; the line integral increased with the effortful swallow. Preopening UES pressure decreased significantly for the Mendelsohn, while postclosure pressure tended to increase insignificantly for both maneuvers. UES area and line integrals as well as nadir UES pressure duration increased with both maneuvers. Maneuver-dependent changes were observed primarily at the velopharynx and UES. These regions are critical to safe swallowing, as the velopharynx provides positive pressure at the bolus tail while the UES allows a bolus to enter the esophagus without risk of regurgitation. Integrals were more responsive than maximum pressure or duration and should be investigated further.
Authors:
Matthew R Hoffman; Jason D Mielens; Michelle R Ciucci; Corinne A Jones; Jack J Jiang; Timothy M McCulloch
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-04
Journal Detail:
Title:  Dysphagia     Volume:  27     ISSN:  1432-0460     ISO Abbreviation:  Dysphagia     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-02-13     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  8610856     Medline TA:  Dysphagia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-26     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Deglutition / physiology*
Esophageal Sphincter, Upper / physiology*
Female
Humans
Male
Manometry
Pharynx / physiology*
Pressure
Tongue / physiology*
Water
Young Adult
Grant Support
ID/Acronym/Agency:
R21 DC011130/DC/NIDCD NIH HHS; R21 DC011130A/DC/NIDCD NIH HHS; R33 DC011130/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
059QF0KO0R/Water
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TGF? modulates cell-to-cell communication in early epithelial-to-mesenchymal transition.
Next Document:  Distal Esophageal Spasm.