Document Detail


High prevalence of hypovitaminosis D status in patients with early Parkinson disease.
MedLine Citation:
PMID:  21403017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vitamin D insufficiency has been reported to be more common in patients with Parkinson disease (PD) than in healthy control subjects, but it is not clear whether having a chronic disease causing reduced mobility contributes to this relatively high prevalence.
OBJECTIVE: To examine the prevalence of vitamin D insufficiency in a cohort of untreated patients with early PD (diagnosed within 5 years of study entry). DESIGN, SETTING, AND PATIENTS The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) cohort is a well-characterized cohort of subjects with early, nondisabling PD. The cohort is well suited for examining the prevalence of vitamin D insufficiency early in the course of the disease. We conducted a survey study of vitamin D status in stored blood samples from patients with PD enrolled in the placebo group of the DATATOP trial. Samples from baseline visits and end point/final visits (mean [SD], 18.9 [13.1] months) were analyzed for 25-hydroxyvitamin D (25[OH]D) concentration in blinded fashion.
MAIN OUTCOME MEASURES: The mean vitamin D concentration and the prevalence of vitamin D insufficiency at baseline and end point/final visits.
RESULTS: Among 199 subjects, 170 (85.4%) had samples from the baseline and end point visits available for analysis; 13 were excluded (10 with low probability of having PD and 3 with 25[OH]D concentrations>3 SDs above the mean). In the remaining 157 subjects, the mean (SD) 25(OH)D concentrations at the baseline and end point visits were 26.3 (8.6) ng/mL and 31.3 (9.0) ng/mL, respectively (to convert to nanomoles per liter, multiply by 2.496). The prevalence of vitamin D insufficiency (25[OH]D concentration<30.0 ng/mL) was 69.4% at baseline and 51.6% at the end point.
CONCLUSIONS: The prevalence of vitamin D insufficiency in patients with early PD was similar to or higher than those reported in previous studies. Vitamin D concentrations did not decline during progression of PD. Further studies are needed to elucidate the natural history and significance of vitamin D insufficiency in PD.
Authors:
Marian L Evatt; Mahlon R DeLong; Meena Kumari; Peggy Auinger; Michael P McDermott; Vin Tangpricha;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  68     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-05-19     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Emory University School of Medicine, 1841 Clifton Rd NE, Atlanta, GA 30329, USA. mevatt@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Disease Progression
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hydroxycholecalciferols / blood
Male
Middle Aged
Nutritional Status
Parkinson Disease / complications*,  epidemiology*
Seasons
Socioeconomic Factors
Vitamin D / therapeutic use
Vitamin D Deficiency / complications*,  epidemiology*
Vitamins / therapeutic use
Grant Support
ID/Acronym/Agency:
K23 AR054334/AR/NIAMS NIH HHS; NS 24778/NS/NINDS NIH HHS; T32 DK007298/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Hydroxycholecalciferols; 0/Vitamins; 1406-16-2/Vitamin D
Comments/Corrections
Comment In:
Arch Neurol. 2011 Dec;68(12):1615-6   [PMID:  22159068 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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