| High prevalence of Fluoroquinolone- and Methicillin-resistant Staphylococcus pseudintermedius isolates from canine pyoderma and otitis externa in veterinary teaching hospital. | |
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MedLine Citation:
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PMID: 20467256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, a total of 74 Staphylococcus pseudintermedius isolates were collected from clinical cases of canine pyoderma and otitis externa in Korea. In this study, we examined in vitro fluoroquinolone resistance among those isolates using a standard disk diffusion technique. The results demonstrated that approximately 18.9% to 27.0% of the isolates possessed bacterial resistance to both veterinary- and human-licensed fluoroquinolones except one isolate, including moxifloxacin (18.9% resistance), levofloxacin (20.3% resistance), ofloxacin (24.3% resistance), ciprofloxacin (25.7% resistance), and enrofloxacin (27.0% resistance). Most surprisingly, 14 out of 74 (18.9%) isolates were resistant to all the five fluoroquinolones evaluated. Moreover, a PCR detection of the methicillin resistance gene (mecA) among the 74 isolates revealed that 13 out of 25 (52.0%) mecA-positive isolates, but only 7 out of 49 (14.3%) mecA-negative isolates, were resistant to one or more fluoroquinones. Taken together, our results imply that bacterial resistance to both veterinary- and human-use fluoroquinolones becomes prevalent among the S. pseudintermedius isolates from canine pyoderma and otitis externa in Korea as well as that the high prevalence of the mecA-positive S. pseudintermedius isolates carrying multiple fluoroquinolone resistance could be a potential public health problem. |
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Authors:
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Jong-Hyun Yoo; Jang W Yoon; So-Young Lee; Hee-Myung Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of microbiology and biotechnology Volume: 20 ISSN: 1017-7825 ISO Abbreviation: J. Microbiol. Biotechnol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431852 Medline TA: J Microbiol Biotechnol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 798-802 Citation Subset: IM |
Affiliation:
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BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, Konkuk University, Seoul 143-701, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacology, therapeutic use Bacterial Proteins / chemistry, genetics DNA, Bacterial / chemistry, genetics Dog Diseases / drug therapy, microbiology* Dogs Drug Resistance, Multiple, Bacterial / genetics Fluoroquinolones / pharmacology, therapeutic use Methicillin / pharmacology, therapeutic use Otitis Externa / drug therapy, microbiology, veterinary* Polymerase Chain Reaction Pyoderma / drug therapy, microbiology, veterinary* Staphylococcal Infections / drug therapy, microbiology, veterinary* Staphylococcus / genetics, isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bacterial Proteins; 0/DNA, Bacterial; 0/Fluoroquinolones; 0/MecA protein, Staphylococcus pseudintermedius; 61-32-5/Methicillin |
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