Document Detail

High-Pressure Accelerated Asymmetric Organocatalytic Friedel-Crafts Alkylation of Indoles with Enones: Application to Quaternary Stereogenic Centers Construction.
MedLine Citation:
PMID:  22397622     Owner:  NLM     Status:  Publisher    
An organocatalytic Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones was found to be efficiently accelerated under high-pressure conditions with a low loading of chiral primary amine salts with good yield and enantioselectivity up to 90%. This approach also allows, for the first time, selected indole derivatives containing quaternary stereogenic centers to be obtained from prochiral β,β-disubstituted enones with an enantioselectivity up to 80%.
Dawid Lyżwa; Krzysztof Dudziński; Piotr Kwiatkowski
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-7
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
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