| High-Pressure Accelerated Asymmetric Organocatalytic Friedel-Crafts Alkylation of Indoles with Enones: Application to Quaternary Stereogenic Centers Construction. | |
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MedLine Citation:
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PMID: 22397622 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An organocatalytic Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones was found to be efficiently accelerated under high-pressure conditions with a low loading of chiral primary amine salts with good yield and enantioselectivity up to 90%. This approach also allows, for the first time, selected indole derivatives containing quaternary stereogenic centers to be obtained from prochiral β,β-disubstituted enones with an enantioselectivity up to 80%. |
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Authors:
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Dawid Lyżwa; Krzysztof Dudziński; Piotr Kwiatkowski |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-7 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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