| High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol. | |
| | |
MedLine Citation:
|
PMID: 20511449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: We hypothesized that patients with high HDL-cholesterol (HDL-C) and ischemic heart disease (IHD) may have dysfunctional HDL or unrecognized nonconventional risk factors. METHODS: Individuals with IHD (Copenhagen University Hospital) and either high HDL-C (n = 53; women >or=735 mg/L; men >or=619 mg/L) or low HDL-C (n = 42; women <or=387 mg/L; men <or=341 mg/L) were compared with individuals without IHD (Copenhagen City Heart Study) matched by age, sex, and HDL-C concentrations (n = 110). All participants had concentrations within reference intervals for LDL-C (<1600 mg/L) and triglyceride (<1500 mg/L), and none were treated with lipid-lowering medications. Pre-beta(1) HDL and phospholipid transfer protein concentrations were measured by using commercial kits and lecithin:cholesterol acyltransferase (LCAT) activity by using a proteoliposome cholesterol esterification assay. RESULTS: Pre-beta(1) HDL concentrations were 2-fold higher in individuals with IHD vs no IHD in both the high [63 (5.7) vs 35 (2.3) mg/L; P < 0.0001] and low HDL-C [49 (5.0) vs 27 (1.5) mg/L; P = 0.001] groups. Low LCAT activity was also associated with IHD in the high [95.2 (6.7) vs 123.0 (5.3) micromol x L(-1) x h(-1); P = 0.002] and low [93.4 (8.3) vs 113.5 (4.9) micromol x L(-1) . h(-1); P = 0.03] HDL-C groups. ROC curves for pre-beta(1) HDL in the high-HDL-C groups yielded an area under the curve of 0.71 (95% CI: 0.61-0.81) for predicting IHD, which increased to 0.92 (0.87-0.97) when LCAT was included. Similar results were obtained for low HDL-C groups. An inverse correlation between LCAT activity and pre-beta(1) HDL was observed (r(2) = 0.30; P < 0.0001) in IHD participants, which was stronger in the low HDL-C group (r(2) = 0.56; P < 0.0001). CONCLUSIONS: IHD was associated with high pre-beta(1) HDL concentrations and low LCAT levels, yielding correct classification in more than 90% of the IHD cases for which both were measured, thus making pre-beta(1) HDL concentration and LCAT activity level potentially useful diagnostic markers for cardiovascular disease. |
| | |
Authors:
|
Amar A Sethi; Maureen Sampson; Russell Warnick; Nehemias Muniz; Boris Vaisman; Børge G Nordestgaard; Anne Tybjaerg-Hansen; Alan T Remaley |
Related Documents
:
|
10894819 - Increased production of hdl apoa-i in homozygous familial defective apob-100. 9436629 - Cholesterol efflux effect of high density lipoprotein is impaired by whole cigarette sm... 11583069 - Gemfibrozil prevents major coronary events by increasing hdl-cholesterol and more. 19485919 - Hdl therapy for the treatment of cardiovascular diseases. 20641119 - A very high prevalence of low hdl cholesterol in spanish patients with acute coronary s... 17438339 - Effects of apoa-v on hdl and vldl metabolism in apoc3 transgenic mice. 3982879 - The preterm rabbit: a model for the study of acute and chronic effects of premature birth. 1269849 - Effect of high fat vs. high carbohydrate feeding on the development of obesity in weanl... 11204129 - Effect of long-term oral administration of an immunostimulant diet on innate immunity i... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-28 |
Journal Detail:
|
Title: Clinical chemistry Volume: 56 ISSN: 1530-8561 ISO Abbreviation: Clin. Chem. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-29 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 1128-37 Citation Subset: IM |
Affiliation:
|
NIH, National Heart Lung and Blood Institute, Lipoprotein Metabolism Section, Bethesda, MD, USA. amars@pacbio.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers
/
blood Cholesterol, HDL / blood* Female High-Density Lipoproteins, Pre-beta / blood* Humans Lecithins / blood* Male Middle Aged Myocardial Ischemia / blood*, diagnosis Risk Factors Sterol O-Acyltransferase / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Cholesterol, HDL; 0/High-Density Lipoproteins, Pre-beta; 0/Lecithins; EC 2.3.1.26/Sterol O-Acyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Critique of the Hypothesis and a Defense of the Question as Frameworks for Experimentation.
Next Document: First- and Second-Trimester ADAM12s in Down Syndrome Screening.