Document Detail

High plasma concentrations of transforming growth factor-β and tissue inhibitor of metalloproteinase-1: potential non-invasive predictors for electroanatomical remodeling of atrium in patients with non-valvular atrial fibrillation.
MedLine Citation:
PMID:  21186331     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The degree of electroanatomical remodeling of the left atrial (LA) affects the clinical outcome after rhythm control of atrial fibrillation (AF). Our hypothesis was that plasma concentrations of transforming growth factor (TGF)-β and tissue inhibitor of metalloproteinase (TIMP)-1 reflect LA voltage and structural remodeling in patients with non-valvular AF.
METHODS AND RESULTS: In the study, 242 patients (male 79.4%, 55.1 ± 11.0 years old) with AF (155 paroxysmal AF, 87 persistent AF) underwent catheter ablation. Pre-ablation plasma concentrations of TGF-β and TIMP-1 and the degree of electroanatomical remodeling quantified by LA voltage map (NavX) and 3D-CT were evaluated. The mean LA voltage and volume were compared in patients with high TGF-β (≥10.0 ng/ml, H-TGF) vs. low TGF-β (<10.0 ng/ml, L-TGF) and high TIMP-1 (≥1.1 ng/ml, H-TIMP) vs. low TIMP-1 (<1.1 ng/ml, L-TIMP). Patients with H-TGF had lower mean LA voltage (P=0.014) and greater LA volume (P=0.022), particularly, posterior venous LA volume (P=0.005) than those with L-TGF. In patients with H-TIMP, the mean LA voltage (P=0.019) was lower than those with L-TIMP. LA volume was significantly higher (P<0.001) in patients with ejection fraction ≤58% than those with >58%.
CONCLUSIONS: In patients with non-valvular AF, high plasma concentrations TGF-β and TIMP-1 and low ejection fraction were closely related with electroanatomical remodeling of LA.
Sook Kyoung Kim; Jae Hyung Park; Jong Youn Kim; Jong Il Choi; Boyoung Joung; Moon-Hyoung Lee; Sung Soon Kim; Young-Hoon Kim; Hui-Nam Pak
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-21
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-07-07     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  557-64     Citation Subset:  IM    
Yonsei University Health System, 250 Seungsanno, Seodaemun-gu, Seoul 120-752, Republic of Korea.
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MeSH Terms
Atrial Fibrillation / blood*,  pathology*,  physiopathology
Biological Markers / blood
Electrophysiologic Techniques, Cardiac
Electrophysiological Phenomena / physiology
Heart Atria / pathology*,  physiopathology
Middle Aged
Predictive Value of Tests
Retrospective Studies
Stroke Volume / physiology
Tissue Inhibitor of Metalloproteinase-1 / blood*
Transforming Growth Factor beta / blood*
Reg. No./Substance:
0/Biological Markers; 0/Tissue Inhibitor of Metalloproteinase-1; 0/Transforming Growth Factor beta
Comment In:
Circ J. 2011;75(3):536-7   [PMID:  21301130 ]
Erratum In:
Circ J. Circ J. 2011 Apr;75(4):1013.

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