Document Detail


High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.
MedLine Citation:
PMID:  16341121     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HMGA gene overexpression and rearrangements are frequent in several tumours, but their oncogenic function is still unclear. Here we report of a physical and functional interaction between High Mobility Group A1 (HMGA1) protein and p53 oncosuppressor. We found that HMGA1 binds p53 in vitro and in vivo, and both proteins are present in the same complexes bound to the Bax gene promoter. HMGA1 interferes with the p53-mediated transcription of p53 effectors Bax and p21(waf1) while cooperates with p53 in the transcriptional activation of the p53 inhibitor mdm2. This transcriptional modulation is associated with a reduced p53-dependent apoptosis in cells expressing exogenous HMGA1 and p53, or in cells expressing endogenously the proteins and in which p53 was activated by UV-irradiation. Furthermore, antisense inhibition of HMGA1b expression dramatically increases the UV-induced p53-mediated apoptosis. These data define a new physical and functional interaction between HMGA1 and p53 that modulates transcription of p53 target genes and inhibits apoptosis.
Authors:
G M Pierantoni; C Rinaldo; F Esposito; M Mottolese; S Soddu; A Fusco
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication     Date:  2005-12-09
Journal Detail:
Title:  Cell death and differentiation     Volume:  13     ISSN:  1350-9047     ISO Abbreviation:  Cell Death Differ.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-11-21     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9437445     Medline TA:  Cell Death Differ     Country:  England    
Other Details:
Languages:  eng     Pagination:  1554-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
Cell Line
Cyclin-Dependent Kinase Inhibitor p21 / metabolism
HMGA1b Protein / metabolism*
Humans
Promoter Regions, Genetic
Protein Binding
Proto-Oncogene Proteins c-mdm2 / metabolism
Transcription, Genetic
Transcriptional Activation
Tumor Suppressor Protein p53 / metabolism*
Ultraviolet Rays
bcl-2-Associated X Protein / genetics,  metabolism
Chemical
Reg. No./Substance:
0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Tumor Suppressor Protein p53; 0/bcl-2-Associated X Protein; 124543-08-4/HMGA1b Protein; EC 6.3.2.19/MDM2 protein, human; EC 6.3.2.19/Proto-Oncogene Proteins c-mdm2
Comments/Corrections
Retraction In:
Cell Death Differ. 2014 Mar;21(3):503   [PMID:  24317197 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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