Document Detail

High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis.
MedLine Citation:
PMID:  20498174     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Low oxygen saturation appears to decrease the risk of severe retinopathy of prematurity (ROP) in preterm newborns when administered during the first few weeks after birth. High oxygen saturation seems to reduce the risk at later postmenstrual ages (PMAs). However, previous clinical studies are not conclusive individually.
OBJECTIVE: To perform a systematic review and meta-analysis to report the association between severe ROP incidence of premature infants with high or low target oxygen saturation measured by pulse oximetry.
METHODS: Studies were identified through PubMed and Embase literature searches through May 2009 by using the terms "retinopathy of prematurity and oxygen" or "retinopathy of prematurity and oxygen therapy." We selected 10 publications addressing the association between severe ROP and target oxygen saturation measured by pulse oximetry. Using a random-effects model we calculated the summary-effect estimate. We visually inspected funnel plots to examine possible publication bias.
RESULTS: Low oxygen saturation (70%-96%) in the first several postnatal weeks was associated with a reduced risk of severe ROP (risk ratio [RR]: 0.48 [95% confidence interval (CI): 0.31-0.75]). High oxygen saturation (94%-99%) at > or = 32 weeks' PMA was associated with a decreased risk for progression to severe ROP (RR: 0.54 [95% CI: 0.35-0.82]).
CONCLUSIONS: Among preterm infants with a gestational age of < or = 32 weeks, early low and late high oxygen saturation were associated with a reduced risk for severe ROP. We feel that a large randomized clinical trial with long-term developmental follow-up is warranted to confirm this meta-analytic result.
Minghua L Chen; Lei Guo; Lois E H Smith; Christiane E L Dammann; Olaf Dammann
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-24
Journal Detail:
Title:  Pediatrics     Volume:  125     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-07-27     Revised Date:  2014-05-22    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1483-92     Citation Subset:  AIM; IM    
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MeSH Terms
Effect Modifier, Epidemiologic
Infant, Newborn
Infant, Premature
Oxygen / blood*
Retinopathy of Prematurity / blood*,  epidemiology
Risk Assessment
Severity of Illness Index
Grant Support
1R21EY0109253-01/EY/NEI NIH HHS; R01 EY017017/EY/NEI NIH HHS
Reg. No./Substance:

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