| High Levels of Maternal Serum IL-17 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus. | |
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MedLine Citation:
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PMID: 21736662 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Citation Torricelli M, Bellisai F, Novembri R, Galeazzi LR, Iuliano A, Voltolini C, Spreafico A, Galeazzi M, Petraglia F. High levels of maternal serum IL-17 and activin A in pregnant women affected by systemic lupus erythematosus. Am J Reprod Immunol 2011; 66: 84-89 Problem To evaluate changes of serum IL-17, activin A, follistatin, and other cytokines during pregnancy in women with systemic lupus erythematosus (SLE). Method of study A group of patients with SLE and controls were longitudinally studied, collecting a blood sample before and during three trimesters of pregnancy. Serum activin A, follistatin, IL-17, IL-6, IL-10, and TNF-α concentrations were evaluated by specific ELISA. Results Before pregnancy, while serum IL-17, IL-6, IL-10, and TNF-α resulted significantly higher in women with SLE (P < 0.001), activin A and follistatin were not changed. Serum IL-17 concentrations were higher in SLE than in controls with no changes during pregnancy. IL-6 increased in both groups, resulting higher in SLE than in controls only in the first trimester (P < 0.05). IL-10 concentration in SLE increased during pregnancy resulting significantly higher than in controls (P < 0.01). TNF-α levels were higher in SLE than in controls in third trimester (P < 0.01). Serum activin A levels in SLE were significantly higher than in controls (P < 0.001) at third trimester. Conclusion Women with SLE show increased secretions of activin A, IL-17, IL-6, IL-10, and TNF-α during gestation, with a different trend for the various cytokines. These data suggest that patients with SLE have a hyper-reactive immune system, probably receiving a placental contribution. |
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Authors:
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Michela Torricelli; Francesca Bellisai; Romina Novembri; Luna R Galeazzi; Annamaria Iuliano; Chiara Voltolini; Adriano Spreafico; Mauro Galeazzi; Felice Petraglia |
Publication Detail:
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Type: Journal Article Date: 2011-01-24 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 66 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 84-9 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Division of Obstetrics and Gynecology, Department of Pediatric, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy Division of Rheumatology, Clinical Medicine and Immunological Sciences Department, University of Siena, Siena, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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