Document Detail

High levels of endothelin (ET)-1 and aneurysm diameter independently predict growth of stable abdominal aortic aneurysms.
MedLine Citation:
PMID:  19689995     Owner:  NLM     Status:  MEDLINE    
The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/- 7 vs 72 +/- 8 years; P < .029), and initial ET-1 levels (1.31 +/- 0.50 vs 1.13 +/- 0.49 pg/mL; P < .0177) were higher in patients with growth above median. Endothelin 1 (P = .0230) and initial AAA diameter (P = .0019) predicted AAA growth above median in logistic regression. In conclusion, higher initial levels of ET-1 and initial AAA diameter independently predict AAA growth.
Despina Flondell-Sité; Bengt Lindblad; Anders Gottsäter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-18
Journal Detail:
Title:  Angiology     Volume:  61     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  324-8     Citation Subset:  IM    
University of Lund, Vascular Centre, Malmö University Hospital, Malmö, Sweden.
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MeSH Terms
Age Factors
Aged, 80 and over
Aortic Aneurysm, Abdominal / blood*,  mortality,  pathology*
Aortic Rupture / blood,  etiology,  mortality
CD40 Ligand / blood
Endothelin-1 / blood*
Follow-Up Studies
Interleukin-6 / blood
Logistic Models
Risk Factors
Tumor Necrosis Factor-alpha / blood
Reg. No./Substance:
0/Endothelin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 147205-72-9/CD40 Ligand
Comment In:
Angiology. 2010 May;61(4):321-3   [PMID:  20211937 ]

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