| High Levels of Apolipoprotein B/AI Ratio Are Associated With Intracranial Atherosclerotic Stenosis. | |
| | |
MedLine Citation:
|
PMID: 21868729 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: The apolipoprotein B (apoB)/apoAI ratio is recognized as a better indicator of cardiovascular disease than other cholesterol measures. Whether intracranial or extracranial atherosclerosis is more closely associated with an increased apoB/apoAI ratio has not been investigated. METHODS: A total of 464 statin or fibrate naïve Korean patients with acute ischemic stroke was categorized into 3 groups: intracranial (ICAS, n=236), extracranial (n=44), and no cerebral atherosclerotic stenosis (n=184). The apoB/apoAI ratio and demographics, including the presence of metabolic syndrome, were compared among the groups. RESULTS: The ICAS group showed a higher apoB/apoAI ratio (0.81±0.02) than both the extracranial atherosclerotic stenosis (0.74±0.03) and no cerebral atherosclerotic stenosis (0.72±0.02) groups (P<0.002). The ratio was substantially increased (0.93±0.03) in patients with advanced ICAS (≥3 intracranial stenoses). With a multivariable analysis, the highest apoB/apoAI ratio quartile was an independent predictor of ICAS (OR, 2.13; 95% CI, 1.05 to 4.33). A dose-response relationship was observed between the presence of advanced ICAS and the apoB/apoAI ratio quartiles (OR, 4.03; 95% CI, 1.26 to 12.88 for the second quartile; OR, 4.88; 95% CI, 1.54 to 15.49 for the third quartile; and OR, 7.79; 95% CI, 2.41 to 25.16 for the fourth quartile when referenced to the first quartile). Patients having more metabolic syndrome components were more likely to have ICAS, advanced ICAS, and a higher apoB/apoAI ratio (P<0.001 for all). CONCLUSIONS: A higher apoB/apoAI ratio is a predictor of ICAS rather than of extracranial atherosclerotic stenosis or no cerebral atherosclerotic stenosis. The apoB/apoAI ratio might be a biomarker for ICAS in Asian patients with stroke. |
| | |
Authors:
|
Jong-Ho Park; Keun-Sik Hong; Eun-Ja Lee; Juneyoung Lee; Dong-Eog Kim |
Related Documents
:
|
20521049 - High intensity focused ultrasound ablation of pancreatic neuroendocrine tumours: report... 16217179 - Update on the evaluation of pancreatic exocrine status in cystic fibrosis. 17305629 - Non-smoking and non-drinking patients with head and neck squamous cell carcinoma: a dis... 1379569 - Relation of diagnostic serum amylase levels to aetiology and severity of acute pancreat... 7052409 - The diagnosis of abdominal pain in ambulatory male patients. 11054199 - Are diagnostic testing and admission rates higher in non-english-speaking versus englis... 11246729 - Life after cystectomy and orthotopic neobladder versus ileal conduit urinary diversion. 22050539 - The association between inflammatory bowel disease and periodontitis among jordanians: ... 6932649 - Defibrination in adult acute lymphoblastic leukaemia. report of four cases. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-25 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: - ISSN: 1524-4628 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Stroke Center and the Department of Diagnostic Neuroradiology, Kwandong University Myongji Hospital, Goyang, Korea; the Department of Neurology, Inje University Ilsan Paik Hospital, Goyang, Korea; the Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea; and the Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ancrod and Fibrin Formation: Perspectives on Mechanisms of Action.
Next Document: Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot Resolution in Brain Hemorrhage:...