Document Detail

High Interleukin-16 Concentrations in the Early Second Trimester Amniotic Fluid: An Independent Predictive Marker for Preterm Birth.
MedLine Citation:
PMID:  23020666     Owner:  NLM     Status:  Publisher    
Abstract Objective: Infection is believed to be one of frequent and important causes of preterm labor. We attempted to evaluate whether the level of inflammatory markers, e.g. interleukin-16 (IL-16), interleukin-18 (IL-18), and ferritin, in amniotic fluid at early second trimester can predict preterm birth. Methods: Amniotic fluid (AF) samples were collected from 350 pregnant women who had trans-abdominal amniocentesis for genetic indications at 16 to 20 weeks of gestation. AF levels of IL-16, IL-18 and ferritin levels were measured by immunoassay and were correlated with pregnancy outcomes. Results: Among the 350 pregnant women, 58 (16.6%) had preterm birth (< 37 weeks gestation). AF levels of IL-16, IL-18, and ferritin were significantly higher in pregnant women with subsequent preterm birth. Multivariate analyses showed that a quartile higher of AF IL-16 level was significantly associated with preterm birth (OR: 3.09, 95% CI 1.52-6.27, p=0.002). A receiver operating characteristic analysis revealed that an IL-16 cutoff value of 105 pg/ml was a reliable predictor of preterm birth (sensitivity, 90.2%; specificity, 52.7%; negative predictive value, 84.3%). Conclusion: It is feasible to predict preterm birth by measuring the AF levels of IL-16 especially for the pregnant women requiring genetic amniocentesis during early second trimester.
Te-Yao Hsu; Hao Lin; Kuo-Chung Lan; Chia-Yu Ou; Ching-Chang Tsai; Bi-Hua Cheng; Kuender D Yang; Yi-Hsun Wong; Tiao-Hsien Hung; Pi-Yu Hsiao; Hui-Fen Kao
Related Documents :
17590906 - Type a botulin toxin.
25278176 - Azithromycin and other macrolides for prevention of bronchopulmonary dysplasia: a syste...
9326696 - Transcatheter radiofrequency ablation for congenital junctional ectopic tachycardia in ...
19596116 - Giant condyloma with demise secondary to meningococcemia in an infant boy.
16407966 - Lipopolysaccharide-binding protein in noninfected neonates and those with suspected ear...
19520266 - Cerebellar injury in term infants: clinical characteristics, magnetic resonance imaging...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of Gamma Irradiation on Metallothionein Protein Expression in Plantago ovata Forsk.
Next Document:  Insight into the Role of Dissolved Organic Matter in Sorption of Sulfonamide Antibiotics by Semi-Ari...