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High-Intensity Swimming Exercise Reduces Neuropathic Pain in an Animal Model of Complex Regional Pain Syndrome Type I: Evidence for a Role of the Adenosinergic System.
MedLine Citation:
PMID:  23291454     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigated the involvement of the adenosinergic system in antiallodynia induced by exercise in an animal model of complex regional pain syndrome type I (CRPS-I). Furthermore, we analyzed the role of the opioid receptors on exercise-induced analgesia. Ischemia/Reperfusion (IR) mice, nonexercised and exercised, received intraperitoneal injection of caffeine (10 mg/kg, a non selective adenosine receptor antagonist), DPCPX (0.1 mg/kg, a selective adenosine A(1) receptor antagonist), ZM241385 (3 mg/kg, a selective adenosine A(2A) receptor antagonist), adenosine deaminase inhibitor erythro-9-(2-hydroxy-3nonyl) adenine [(EHNA), 5 mg/kg, an adenosine deaminase inhibitor] or naloxone (1 mg/kg, a nonselective opioid receptor antagonist). The results showed that high-intensity swimming exercise reduced mechanical allodynia in an animal model of CRPS-I in mice. The antiallodynic effect caused by exercise was reversed by pretreatment with caffeine, naloxone, DPCPX but it was not modified by ZM241385 treatment. In addition, treatment with EHNA, which suppresses the breakdown of adenosine to inosine, enhanced the pain-relieving effects of the high swimming exercise. This is the first report demonstrating that repeated sessions of high-intensity swimming exercise attenuate mechanical allodynia in an animal model of CRPS-I and that the mechanism involves endogenous adenosine and adenosine A(1) receptors. This study supports the use of high-intensity exercise as an adjunct therapy for CRPS-I treatment.
Authors:
Daniel F Martins; Leidiane Mazzardo-Martins; Fernando Soldi; Juliana Stramosk; Anna Paula Piovezan; Adair R S Santos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ltd.
Affiliation:
Laboratório de Neurobiologia da Dor e Inflamação, Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário - Trindade, Florianópolis, SC, Brazil; Programa de Pós-Graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário - Trindade, Florianópolis, SC, Brazil; Curso de Fisioterapia, Universidade do Sul de Santa Catarina, Campus Grande Florianópolis - Palhoça, SC, Brazil.
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