Document Detail

High-intensity extended swimming exercise reduces pain-related behavior in mice: involvement of endogenous opioids and the serotonergic system.
MedLine Citation:
PMID:  20488763     Owner:  NLM     Status:  MEDLINE    
PERSPECTIVE: Our results indicate that high-intensity extended exercise endogenously controls acute pain by activation of opioidergic and serotonergic pathways. Furthermore, these results support the use of exercise as a nonpharmacological approach for the management of acute pain.
Leidiane Mazzardo-Martins; Daniel F Martins; Rodrigo Marcon; Ubirajara D Dos Santos; Breno Speckhann; Vinícius M Gadotti; André Roberto Sigwalt; Luiz Guilherme A Guglielmo; Adair Roberto Soares Santos
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Publication Detail:
Type:  Journal Article     Date:  2010-05-20
Journal Detail:
Title:  The journal of pain : official journal of the American Pain Society     Volume:  11     ISSN:  1528-8447     ISO Abbreviation:  J Pain     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-01     Completed Date:  2011-03-21     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100898657     Medline TA:  J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1384-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Pain Society. Published by Elsevier Inc. All rights reserved.
Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade, Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, Brazil.
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MeSH Terms
Acetic Acid / toxicity
Behavior, Animal / drug effects,  physiology*
Fenclonine / analogs & derivatives,  pharmacology
Irritants / toxicity
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Opioid Peptides / metabolism*
Pain / chemically induced,  metabolism,  physiopathology
Pain Threshold / drug effects,  physiology*
Serotonin / metabolism*
Swimming / physiology*
Reg. No./Substance:
0/Irritants; 0/Narcotic Antagonists; 0/Opioid Peptides; 23434-96-0/4-chlorophenylalanine methyl ester; 465-65-6/Naloxone; 50-67-9/Serotonin; 64-19-7/Acetic Acid; 7424-00-2/Fenclonine

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