| High-intensity extended swimming exercise reduces pain-related behavior in mice: involvement of endogenous opioids and the serotonergic system. | |
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MedLine Citation:
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PMID: 20488763 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study examined the hyponociceptive effect of swimming exercise in a chemical behavioral model of nociception and the mechanisms involved in this effect. Male mice were submitted to swimming sessions (30 min/d for 5 days). Twenty-four hours after the last session, we noticed that swimming exercise decreased the number of abdominal constriction responses caused by acetic acid compared with the nonexercised group. The hyponociception caused by exercise in the acetic acid test was significantly attenuated by intraperitoneal (i.p.) pretreatment of mice with naloxone (a nonselective opioid receptor antagonist, 1 mg/kg), ρ-chlorophenylalanine methyl ester (PCPA, an inhibitor of serotonin synthesis, 100 mg/kg once a day for 4 consecutive days), and by bilateral adrenalectomy. Collectively, the present results provide experimental evidences indicating for the first time that high-intensity extended swimming exercise reduces pain-related behavior in mice. The mechanisms involve an interaction with opioid and serotonin systems. Furthermore, endogenous opioids released by adrenal glands probably are involved in this effect. PERSPECTIVE: Our results indicate that high-intensity extended exercise endogenously controls acute pain by activation of opioidergic and serotonergic pathways. Furthermore, these results support the use of exercise as a nonpharmacological approach for the management of acute pain. |
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Authors:
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Leidiane Mazzardo-Martins; Daniel F Martins; Rodrigo Marcon; Ubirajara D Dos Santos; Breno Speckhann; Vinícius M Gadotti; André Roberto Sigwalt; Luiz Guilherme A Guglielmo; Adair Roberto Soares Santos |
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Publication Detail:
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Type: Journal Article Date: 2010-05-20 |
Journal Detail:
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Title: The journal of pain : official journal of the American Pain Society Volume: 11 ISSN: 1528-8447 ISO Abbreviation: J Pain Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100898657 Medline TA: J Pain Country: United States |
Other Details:
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Languages: eng Pagination: 1384-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Pain Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade, Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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