Document Detail


High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption.
MedLine Citation:
PMID:  24910199     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Irisin is mainly released from skeletal muscle (myocytes) and promotes thermogenesis by browning of the white adipose tissue. Although exercise has been shown to increase irisin concentration in blood and myocytes via up-regulation peroxisome proliferator receptor γ coactivator-1α (PGC-1α) expression, the influence of exercise intensity on irisin secretion remains unclear. Therefore, we determined circulating irisin responses following a single bout of running at different intensities. Six sedentary males underwent treadmill running under two different conditions: a low-intensity (40% of VO2max) exercise trial (LIE) or a high-intensity (80% of VO2max) exercise trial (HIE). The exercises in LIE and HIE were lasted for 20 and 40 min, respectively. All subjects underwent the two trials on separate days, and a randomized cross-over design was used. Blood samples were collected before (Pre) and immediately after exercise, at 3, 6, and 19 h after exercise. Energy consumption during exercise did not significantly differ between the two trials. HIE significantly increased blood lactate and serum lactate dehydrogenase levels (P < 0.05). Compared with pre-exercise levels, the irisin concentrations were elevated at 6 h (18% increase) and 19 h (23% increase) after HIE, but significantly decreased after LIE. The relative irisin concentrations (compared with pre-exercise levels) were significantly greater in HIE than in LIE immediately after exercise, and at 6 and 19 h after exercise (P < 0.05). These findings suggest that irisin secretion after acute running exercise is affected by exercise intensity, independent of energy consumption.
Authors:
Yoshifumi Tsuchiya; Daisuke Ando; Kazushige Goto; Masataka Kiuchi; Mitsuya Yamakita; Katsuhiro Koyama
Related Documents :
23671429 - The influence of systematic pulse-limited physical exercise on the parameters of the ca...
22875719 - Long-term prognostic value of exercise technetium-99m tetrofosmin myocardial perfusion ...
15071399 - Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart.
18801929 - Insulin-like growth factor i receptor signaling is required for exercise-induced cardia...
19144689 - Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progres...
20300909 - Physical exercise attenuates mptp-induced deficits in mice.
7818449 - Aerobic power and body size affects the exercise-induced stress hormone responses to va...
16543649 - Role of exercise training on pulpal blood flow in diabetic rats.
7400009 - Influence of bronchomotor tone on airway dimensions and resistance in excised dog lungs.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  233     ISSN:  1349-3329     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structure of RPA32 bound to N-terminus of SMARCAL1 redefines the binding interface between RPA32 and...
Next Document:  The a>t polymorphism of the tribbles homolog 1 gene is associated with serum triglyceride concentrat...