Document Detail


High-frequency oscillation for acute respiratory distress syndrome.
MedLine Citation:
PMID:  23339638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV) may reduce this secondary damage.
METHODS: In a multicenter study, we randomly assigned adults requiring mechanical ventilation for ARDS to undergo either HFOV with a Novalung R100 ventilator (Metran) or usual ventilatory care. All the patients had a ratio of the partial pressure of arterial oxygen (PaO) to the fraction of inspired oxygen (FiO) of 200 mm Hg (26.7 kPa) or less and an expected duration of ventilation of at least 2 days. The primary outcome was all-cause mortality 30 days after randomization.
RESULTS: There was no significant between-group difference in the primary outcome, which occurred in 166 of 398 patients (41.7%) in the HFOV group and 163 of 397 patients (41.1%) in the conventional-ventilation group (P=0.85 by the chi-square test). After adjustment for study center, sex, score on the Acute Physiology and Chronic Health Evaluation (APACHE) II, and the initial PaO:FiO ratio, the odds ratio for survival in the conventional-ventilation group was 1.03 (95% confidence interval, 0.75 to 1.40; P=0.87 by logistic regression).
CONCLUSIONS: The use of HFOV had no significant effect on 30-day mortality in patients undergoing mechanical ventilation for ARDS. (Funded by the National Institute for Health Research Health Technology Assessment Programme; OSCAR Current Controlled Trials number, ISRCTN10416500.).
Authors:
Duncan Young; Sarah E Lamb; Sanjoy Shah; Iain MacKenzie; William Tunnicliffe; Ranjit Lall; Kathy Rowan; Brian H Cuthbertson;
Related Documents :
17352798 - Plasma nevirapine levels, adverse events and efficacy of antiretroviral therapy among h...
19383078 - Thyroid dysfunction in patients with chronic hepatitis c: virus- or therapy-related?
2669938 - Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a dou...
16024938 - Long-term results of lamivudine monotherapy in korean patients with hbeag-positive chro...
21427178 - Radiofrequency ablation for hepatocellular carcinoma: use of low vs maximal radiofreque...
25036218 - Clinical and radiographic analysis of an artificial cervical disc: 7-year follow-up fro...
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2013-01-22
Journal Detail:
Title:  The New England journal of medicine     Volume:  368     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-03-07     Revised Date:  2014-06-20    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  806-13     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ISRCTN/ISRCTN10416500
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Algorithms
Anoxia / etiology
Anti-Infective Agents / therapeutic use
Female
High-Frequency Ventilation* / methods
Hospital Mortality
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Respiration, Artificial
Respiratory Distress Syndrome, Adult / complications,  mortality,  therapy*
Treatment Failure
Grant Support
ID/Acronym/Agency:
06/04/01//Department of Health; HTA/06/04/01//Department of Health
Chemical
Reg. No./Substance:
0/Anti-Infective Agents
Investigator
Investigator/Affiliation:
Duncan Young / ; Deborah Ashby / ; Kathy Rowan / ; Steve Drage / ; Tim Walsh / ; Barry Williams / ; Heather House / ; Brian Cuthbertson / ; Sallie Lamb / ; Ranjit Lall / ; Christopher McCabe / ; David Torgerson / ; David Menon / ; Peter Nightingale / ; Duncan Young / ; Peter Macnaughton / ; Brian Cuthbertson / ; Catherine Plowright / ; Bill Tunnicliffe / ; Steve Drage / ; Geoff Bellingan / ; Sanjoy Shah / ; Andrew Padkin / ; Bernard Foex / ; Paul Hughes / ; Khalid Elfituri / ; Frank McAuley / ; Chris Cairns / ; Jonathan Paddle / ; Huw Maddock / ; Nick Coleman / ; Andy Kong / ; Robert Lewis / ; Martin Bewsher / ; Andreas Brodbeck / ; David Pogson / ; Martin Clark / ; Stephen Mousdale / ; Andrew Bodenham / ; Rebecca Cusack / ; Mark Bellamy / ; Henry Paw / ; Jason Cupitt / ; David Higgins / ; Cait Searl / ; Judith Wright /
Comments/Corrections
Comment In:
N Engl J Med. 2013 Jun 6;368(23):2234   [PMID:  23745188 ]
N Engl J Med. 2013 Jun 6;368(23):2233   [PMID:  23738554 ]
Dtsch Med Wochenschr. 2013 Apr;138(16):824   [PMID:  23613351 ]
N Engl J Med. 2013 Feb 28;368(9):863-5   [PMID:  23339640 ]
N Engl J Med. 2013 Jun 6;368(23):2232-3   [PMID:  23738553 ]
N Engl J Med. 2013 Jun 6;368(23):2232   [PMID:  23738552 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Electric-Field Dependence of the Effective Dielectric Constant in Graphene.
Next Document:  High-frequency oscillation in early acute respiratory distress syndrome.