| High-Frequency Oscillation for Acute Respiratory Distress Syndrome. | |
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MedLine Citation:
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PMID: 23339638 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV) may reduce this secondary damage. Methods In a multicenter study, we randomly assigned adults requiring mechanical ventilation for ARDS to undergo either HFOV with a Novalung R100 ventilator (Metran) or usual ventilatory care. All the patients had a ratio of the partial pressure of arterial oxygen (PaO(2)) to the fraction of inspired oxygen (FiO(2)) of 200 mm Hg (26.7 kPa) or less and an expected duration of ventilation of at least 2 days. The primary outcome was all-cause mortality 30 days after randomization. Results There was no significant between-group difference in the primary outcome, which occurred in 166 of 398 patients (41.7%) in the HFOV group and 163 of 397 patients (41.1%) in the conventional-ventilation group (P=0.85 by the chi-square test). After adjustment for study center, sex, score on the Acute Physiology and Chronic Health Evaluation (APACHE) II, and the initial PaO(2):FiO(2) ratio, the odds ratio for survival in the conventional-ventilation group was 1.03 (95% confidence interval, 0.75 to 1.40; P=0.87 by logistic regression). Conclusions The use of HFOV had no significant effect on 30-day mortality in patients undergoing mechanical ventilation for ARDS. (Funded by the National Institute for Health Research Health Technology Assessment Programme; OSCAR Current Controlled Trials number, ISRCTN10416500 .). |
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Authors:
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Duncan Young; Sallie Lamb; Sanjoy Shah; Iain Mackenzie; William Tunnicliffe; Ranjit Lall; Kathy Rowan; Brian H Cuthbertson; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: The New England journal of medicine Volume: - ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From John Radcliffe Hospital (D.Y.) and the University of Oxford (D.Y., S.L.), Oxford; the Bristol Royal Infirmary, Bristol (S.S.); Queen Elizabeth Hospital, Birmingham (I.M., W.T.); Warwick Clinical Trials Unit, University of Warwick, Warwick (R.L.); and Intensive Care National Audit and Research Centre, London (K.R.) - all in the United Kingdom; and the Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (B.H.C.). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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