Document Detail

High fat programming induces glucose intolerance in weanling Wistar rats.
MedLine Citation:
PMID:  20195946     Owner:  NLM     Status:  MEDLINE    
We sought to determine whether maintenance on a high fat diet during defined periods of gestation and lactation induced glucose intolerance in weanling Wistar rats or affected food intake, weight, and glucose concentrations in mothers. Experimental groups comprised mothers and their weanling offspring maintained on a high fat diet during gestation and lactation (HFGL), during gestation only (HFG), or during lactation only (HFL). Maternal food intake, body weight, and fasting blood glucose concentrations were determined during lactation. Glucose tolerance was measured in the three-week-old weanling offspring. After overnight fasting, oral glucose tolerance tests were performed in the weanlings. Glucose was collected at (0), 10, 15, 30 and 60 min. HFGL and HFL weanlings had greater glucose concentrations compared to control weanlings at 10, 15, 30 and 60 min. For HFG weanlings, greater glucose concentrations were only found at 30 min, which normalized at 60 min. In all of the experimental groups, the highest glucose concentrations were demonstrated at 30 min, whereas the peak was achieved at 15 min in the control weanlings. Overt glucose intolerance was induced in weanlings maintained on a high fat diet throughout both gestation and lactation or throughout lactation only. Further, weanlings maintained on a high fat diet solely throughout gestation displayed milder glucose intolerance. Developmental programming with a high fat diet during defined periods of gestation and lactation induces glucose intolerance in weanling rats.
M E Cerf; J Louw
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Publication Detail:
Type:  Journal Article     Date:  2010-03-01
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  42     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  307-10     Citation Subset:  IM    
Copyright Information:
J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart-New York.
Diabetes Discovery Platform, Medical Research Council, Tygerberg, Cape Town, South Africa.
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MeSH Terms
Blood Glucose / metabolism
Body Weight / drug effects
Dietary Fats / pharmacology*
Eating / drug effects
Glucose Intolerance / chemically induced*
Glucose Tolerance Test
Lactation / physiology
Rats, Wistar
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats

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