Document Detail


High education may offer protection against tauopathy in patients with mild cognitive impairment.
MedLine Citation:
PMID:  20413900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau (t-tau) and amyloid-beta42, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy.
Authors:
Sindre Rolstad; Arto Nordlund; Carl Eckerström; Marie H Gustavsson; Kaj Blennow; Pernille J Olesen; Henrik Zetterberg; Anders Wallin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  21     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-02     Revised Date:  2011-02-23    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  221-8     Citation Subset:  IM    
Affiliation:
Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, the Sahlgrenska Academy at Göteborg University, Mölndal, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amyloid beta-Peptides / cerebrospinal fluid
Cognition Disorders / cerebrospinal fluid*,  psychology*
Educational Status*
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Peptide Fragments / cerebrospinal fluid
Psychiatric Status Rating Scales
Statistics, Nonparametric
tau Proteins / cerebrospinal fluid*
Chemical
Reg. No./Substance:
0/Amyloid beta-Peptides; 0/Peptide Fragments; 0/amyloid beta-protein (1-42); 0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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