Document Detail

High-dose vitamin d intervention in infants--effects on vitamin d status, calcium homeostasis, and bone strength.
MedLine Citation:
PMID:  22933541     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Guidelines in Finland recommend 10 μg of vitamin D3 daily for all infants. Recent observations suggest that this may be insufficient to maintain optimal serum 25-hydroxyvitamin D (S-25-OHD).
OBJECTIVE: The aim of the study was to evaluate effects of various vitamin D doses and determine a dose ensuring S-25-OHD of at least 80 nmol/liter in infants without signs of vitamin D excess.
DESIGN: We conducted a randomized double-blind intervention study. Cord blood was obtained at birth for S-25-OHD; 113 infants were randomized to receive vitamin D3 10, 30, or 40 μg/d from age 2 wk to 3 months.
SETTING: An investigator-initiated study was performed in a single maternity hospital in Helsinki, Finland.
MAIN OUTCOME MEASURES: S-25-OHD, calcium homeostasis, and skeletal characteristics were evaluated with peripheral quantitative computed tomography at age 3 months.
RESULTS: Baseline S-25-OHD was similar in all three groups (median, 53 nmol/liter). At 3 months, the mean S-25-OHD values were 88, 124, and 153 nmol/liter, and the minimum values were 46, 57, and 86 nmol/liter in the groups receiving 10, 30, and 40 μg (ANOVA; P < 0.001). No hypercalcemia occurred; plasma calcium, serum PTH, and urine calcium excretion was similar between the groups. Peripheral quantitative computed tomography showed a trend toward larger tibial total bone and cortical bone area with higher vitamin D doses.
CONCLUSION: Vitamin D3 supplementation with up to 40 μg/d from age 2 wk to 3 months was safe and caused no hypercalcemia or hypercalciuria. The 40-μg dose maintained S-25-OHD above 80 nmol/liter in all infants. More extensive and longer intervention studies are necessary to assess long-term effects.
Elisa Holmlund-Suila; Heli Viljakainen; Timo Hytinantti; Christel Lamberg-Allardt; Sture Andersson; Outi Mäkitie
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-08-29
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  97     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-06     Completed Date:  2013-01-25     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4139-47     Citation Subset:  AIM; IM    
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MeSH Terms
Cholecalciferol / administration & dosage*
Dietary Supplements*
Dose-Response Relationship, Drug
Double-Blind Method
Fetal Blood / chemistry*
Infant, Newborn
Treatment Outcome
Vitamin D / analogs & derivatives*,  analysis,  blood
Vitamin D Deficiency / blood
Vitamins / administration & dosage*
Reg. No./Substance:
0/Vitamins; 1406-16-2/Vitamin D; 1C6V77QF41/Cholecalciferol; 64719-49-9/25-hydroxyvitamin D

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