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High-Dose Cyclophosphamide in Comparison with Antithymocyte Globulin for Treatment of Acquired Severe Aplastic Anemia.
MedLine Citation:
PMID:  23313080     Owner:  NLM     Status:  Publisher    
A modified high-dose cyclophosphamide (HD-CTX) plus cyclosporine (CsA) regimen was adopted for severe/very severe aplastic anemia (SAA/VSAA) patients, and the effectiveness was compared with that of antithymocyte globulin (ATG) plus CsA regimen. A total of 121 patients enrolled in this study received either CTX plus CsA (CTX group, 48 cases) or ATG plus CSA (ATG group, 73 cases). The early death rate was 4.2% in CTX group and 8.2% in ATG group, showing no significant difference (p=0.312). The total response rate in CTX group and in ATG group was 54.2% and 57.5% at 3 months, 64.6% and 72.6% at 6 months, and 72.9% and 78.1% at 12 months, respectively (p>0.05). The overall 5-year survival rate was 81.2% and 80.7%, and the event free survival rate was 68.2% and 67.3% in CTX and ATG groups, respectively (p>0.05). The total medical cost of CTX group was 54.8% less than that of ATG regimen (p=0.000). In summary, treatment of SAA/VSAA with CTX plus CsA has comparable effectiveness to conventional regimen and less cost.
Fengkui Zhang; Li Zhang; Liping Jing; Kang Zhou; Huijun Wang; Guangxin Peng; Yang Li; Yuan Li; Jianping Li; Lei Ye; Lihui Shi; Huihui Fan; Xin Zhao; Yulin Chu; Yushu Hao; Jianxiang Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Experimental hematology     Volume:  -     ISSN:  1873-2399     ISO Abbreviation:  Exp. Hematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
Department of Anemia Therapeutic Centre, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China. Electronic address:
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