Document Detail

High cytomegalovirus load and prolonged virus excretion in breast milk increase risk for viral acquisition by very low birth weight infants.
MedLine Citation:
PMID:  19687768     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Breast milk is the main source of postnatal human cytomegalovirus (HCMV) infection. The aim of this study was to assess the relationship between HCMV load in breast milk and viral transmission to very low birth weight (VLBW) infants. METHODS: Breast-fed VLBW infants who were born to HCMV-seropositive mothers and who were managed in a neonatal intensive care unit were enrolled in the study. Blood from mothers and infants was tested for HCMV antibodies after birth. Breast milk was collected for viral culture and HCMV load measurement. Urine from the babies was obtained for HCMV-DNA detection. Symptoms of HCMV infection were recorded and evaluated by neonatologists. RESULTS: Of the 23 evaluated mothers during a 1-year period, 19 were HCMV seropositive; 17 of the women had detectable HCMV-DNA in their breast milk whey. Of the 23 infants born to the 19 seropositive mothers, 8 infants of 8 mothers had HCMV-DNA detected in the urine, indicating that they were infected, even though the breast milk was always frozen prior to feeding. Three infected infants had symptoms. At 4 weeks after delivery, the median viral load in breast milk from mothers of the 8 infected infants was significantly higher than that from mothers of the 15 noninfected infants (P = 0.04). HCMV was detectable in breast milk for a significantly longer period in mothers of infected infants (7.5 vs. 2.6 weeks P = 0.03). CONCLUSIONS: High HCMV load and prolonged virus excretion in breast milk are maternal risk factors for viral transmission to VLBW infants.
Wai-Tim Jim; Chyong-Hsin Shu; Nan-Chang Chiu; Jui-Hsing Chang; Han-Yang Hung; Chun-Chih Peng; Hsin-An Kao; Tsai-Yin Wei; Chia-Lien Chiang; Fu-Yuan Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  28     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  891-4     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / transmission*
DNA, Viral / genetics,  isolation & purification
Infant, Newborn
Infant, Very Low Birth Weight*
Infectious Disease Transmission, Vertical*
Milk, Human / virology*
Polymerase Chain Reaction / methods
Pregnancy Complications, Infectious / virology*
Time Factors
Urine / virology
Viral Load*
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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