| High cytomegalovirus load and prolonged virus excretion in breast milk increase risk for viral acquisition by very low birth weight infants. | |
| | |
MedLine Citation:
|
PMID: 19687768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Breast milk is the main source of postnatal human cytomegalovirus (HCMV) infection. The aim of this study was to assess the relationship between HCMV load in breast milk and viral transmission to very low birth weight (VLBW) infants. METHODS: Breast-fed VLBW infants who were born to HCMV-seropositive mothers and who were managed in a neonatal intensive care unit were enrolled in the study. Blood from mothers and infants was tested for HCMV antibodies after birth. Breast milk was collected for viral culture and HCMV load measurement. Urine from the babies was obtained for HCMV-DNA detection. Symptoms of HCMV infection were recorded and evaluated by neonatologists. RESULTS: Of the 23 evaluated mothers during a 1-year period, 19 were HCMV seropositive; 17 of the women had detectable HCMV-DNA in their breast milk whey. Of the 23 infants born to the 19 seropositive mothers, 8 infants of 8 mothers had HCMV-DNA detected in the urine, indicating that they were infected, even though the breast milk was always frozen prior to feeding. Three infected infants had symptoms. At 4 weeks after delivery, the median viral load in breast milk from mothers of the 8 infected infants was significantly higher than that from mothers of the 15 noninfected infants (P = 0.04). HCMV was detectable in breast milk for a significantly longer period in mothers of infected infants (7.5 vs. 2.6 weeks P = 0.03). CONCLUSIONS: High HCMV load and prolonged virus excretion in breast milk are maternal risk factors for viral transmission to VLBW infants. |
| | |
Authors:
|
Wai-Tim Jim; Chyong-Hsin Shu; Nan-Chang Chiu; Jui-Hsing Chang; Han-Yang Hung; Chun-Chih Peng; Hsin-An Kao; Tsai-Yin Wei; Chia-Lien Chiang; Fu-Yuan Huang |
Related Documents
:
|
12613848 - Sialyloligosaccharides in human and bovine milk and in infant formulas: variations with... 20521278 - Food processing increases casein resistance to simulated infant digestion. 16176918 - Human milk research for answering questions about human health. 2485578 - Prevention of iron deficiency by milk fortification. the chilean experience. 11339168 - High-technology breastfeeding. 11817188 - Neonatal complications of preterm premature rupture of membranes. pathophysiology and m... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Pediatric infectious disease journal Volume: 28 ISSN: 1532-0987 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
|
Languages: eng Pagination: 891-4 Citation Subset: IM |
Affiliation:
|
Division of Neonatology, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cytomegalovirus
/
isolation & purification* Cytomegalovirus Infections / transmission* DNA, Viral / genetics, isolation & purification Female Humans Infant, Newborn Infant, Very Low Birth Weight* Infectious Disease Transmission, Vertical* Male Milk, Human / virology* Polymerase Chain Reaction / methods Pregnancy Pregnancy Complications, Infectious / virology* Time Factors Urine / virology Viral Load* |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Testosterone and unconscious positive priming increase human motivation separately.
Next Document: Immune reconstitution inflammatory syndrome in human immunodeficiency virus-infected children in Per...