| High-contrast PET of melanoma using (18)F-MEL050, a selective probe for melanin with predominantly renal clearance. | |
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MedLine Citation:
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PMID: 20150254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the novel probe (18)F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide ((18)F-MEL050) for the imaging of primary and metastatic melanoma. METHODS: PET using (18)F-MEL050 was performed in murine models of melanoma. The specificity of (18)F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. (18)F-MEL050 PET results were compared with (18)F-FDG PET, the current standard in melanoma molecular imaging. To test the ability of (18)F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, and results correlated with physical assessment of tumor burden in the lungs. RESULTS: In pigmented B16-F0 grafts, (18)F-MEL050 PET yielded a tumor-to-background ratio of approximately 20:1 at 1 h and greater than 50:1 at 2 and 3 h. In the B16-F0 melanoma allograft model, tumor-to-background ratio was more than 9-fold higher for (18)F-MEL050 than for (18)F-FDG (50.9 +/- 6.9 vs. 5.8 +/- 0.5). No uptake was observed in the amelanotic melanoma xenografts. Intense uptake of (18)F-MEL050 was evident in metastatic lesions in the lungs of B16-BL6 tumor-bearing mice on PET at 2 h after tracer injection, with high concordance between (18)F-MEL050 accumulation on PET/CT and tumor burden determined at necroscopy. CONCLUSION: (18)F-MEL050 has a rapid tumor uptake and high retention with specificity for melanin, suggesting great potential for noninvasive clinical evaluation of suspected metastatic melanoma. |
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Authors:
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Delphine Denoyer; Ivan Greguric; Peter Roselt; Oliver C Neels; Nicolas Aide; Stephen R Taylor; Andrew Katsifis; Donna S Dorow; Rodney J Hicks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-11 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 441-7 Citation Subset: IM |
Affiliation:
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Centre for Molecular Imaging and Translational Research Laboratory, Peter MacCallum Cancer Centre, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Cell Line, Tumor Cell Transformation, Neoplastic Contrast Media / chemistry, diagnostic use, metabolism Female Fluorine Radioisotopes / chemistry* Fluorodeoxyglucose F18 / diagnostic use Humans Kidney / metabolism* Melanins / metabolism* Melanoma / metabolism, pathology, radiography, radionuclide imaging* Mice Neoplasm Metastasis Niacinamide / analogs & derivatives*, chemistry, diagnostic use, metabolism Positron-Emission Tomography* Pyridines / chemistry, diagnostic use*, metabolism* Substrate Specificity Tomography, X-Ray Computed Transplantation, Homologous Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Fluorine Radioisotopes; 0/Melanins; 0/N-(2-(diethylamino)ethyl)-6-fluoronicotinamide; 0/Pyridines; 63503-12-8/Fluorodeoxyglucose F18; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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