Document Detail


High Coffee Intake, but Not Caffeine, is Associated with Reduced Estrogen Receptor Negative and Postmenopausal Breast Cancer Risk with No Effect Modification by CYP1A2 Genotype.
MedLine Citation:
PMID:  23530639     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were recruited through the Ontario Cancer Registry and controls (n = 3,427) through random digit dialing. Logistic regression was used to evaluate associations between breast cancer risk and intakes of 7 caffeine-containing items and total caffeine, and examine whether a genetic variant in CYP1A2 (rs762551) modified these associations. Analyses were stratified by estrogen receptor (ER), menopausal, and smoking status. Generally, coffee and caffeine were not associated with breast cancer risk; however, a significant reduction in risk was observed with the highest category of coffee consumption [≥5 cups per day vs. never, multivariate-adjusted odds ratio (MVOR) = 0.71, 95% confidence interval (CI): 0.51, 0.98]. Variant rs762551 did not modify associations. In stratified analyses, high coffee intake was associated with reduced risk of ER- (MVOR = 0.41, 95% CI: 0.19, 0.92) and postmenopausal breast cancer (MVOR = 0.63, 95% CI: 0.43, 0.94). High coffee consumption, but not total caffeine, may be associated with reduced risk of ER- and postmenopausal breast cancers, independent of CYP1A2 genotype. Further studies are needed to replicate these findings.
Authors:
Elizabeth C Lowcock; Michelle Cotterchio; Laura N Anderson; Beatrice A Boucher; Ahmed El-Sohemy
Related Documents :
23641039 - A multigene expression assay to predict local recurrence risk for ductal carcinoma in s...
24580799 - Physical activity and the risk of postmenopausal breast cancer - the norwegian women an...
16848849 - Surgical treatment of solitary metastasis in the male breast from non-small cell lung c...
25018299 - 0200 night shiftwork and breast cancer survival in danish women.
24317179 - Lifetime cigarette smoking and breast cancer prognosis in the after breast cancer pooli...
23543779 - Estrogen plus progestin and breast cancer incidence and mortality in the women's health...
18203649 - Cytokeratin fragments in the serum: their utility for the management of oral cancer.
17382859 - The preferred treatment for young women with breast cancer--mastectomy versus breast co...
16868059 - Effect of raloxifene on bone mineral density in premenopausal women at increased risk o...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition and cancer     Volume:  65     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-409     Citation Subset:  IM    
Affiliation:
a Prevention and Cancer Control, Cancer Care Ontario , Toronto , Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Population versus hospital controls in the assessment of dietary intake of isoflavone for case-contr...
Next Document:  Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density.