Document Detail

High body mass index is an important risk factor for the development of type 2 diabetes.
MedLine Citation:
PMID:  22821094     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to establish a causal relationship between excess body weight and the onset of diabetes in a retrospective cohort study.
METHODS: This 10-year observational cohort study investigated 969 men and 585 women (23 to 80 years of age), who underwent voluntary complete medical check-ups and an annual 75-g oral glucose tolerance test (75 g-OGTT). Participants with fasting plasma glucose ≥126 mg/dL, 2-h glucose level in a 75 g-OGTT ≥200 mg/dL and/or received medical treatment for type 2 diabetes during the previous year were considered as new-onset diabetics. We assessed the independent contribution of increased BMI to the risk of developing type 2 diabetes with Cox proportional hazard model.
RESULT: During the follow-up period, we diagnosed 86 men and 49 women with new-onset type 2 diabetes. In the Cox proportional hazards model, the risk of diabetes mellitus increased with increasing BMI, even after adjusting for age, sex, blood pressure, metabolic profiles, and insulin resistance. In the final model, setting BMI less than 25 as a reference group, the Hazard ratios for diabetes mellitus was 3.12 for those with a BMI of 25-27.4 and it was increased to 3.80 for participants with a BMI of 27.5 or higher.
CONCLUSION: Overweight/obesity (high BMI) is an independent and dose-dependent risk factor for type 2 diabetes in overweight Japanese patients. Our results confirmed the usefulness of BMI as a classic parameter, and the importance of lifestyle modification and better management among people with overweight/obesity for prevention of type 2 diabetes mellitus.
Hironobu Sanada; Hirohide Yokokawa; Minoru Yoneda; Junichi Yatabe; Midori Sasaki Yatabe; Scott M Williams; Robin A Felder; Pedro A Jose
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Publication Detail:
Type:  Journal Article     Date:  2012-07-15
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  51     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-23     Completed Date:  2013-01-29     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1821-6     Citation Subset:  IM    
Division of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Japan.
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MeSH Terms
Aged, 80 and over
Asian Continental Ancestry Group
Blood Glucose / metabolism
Body Mass Index*
Cohort Studies
Diabetes Mellitus, Type 2 / blood,  etiology*,  pathology*
Glucose Tolerance Test
Middle Aged
Obesity / complications
Overweight / complications
Proportional Hazards Models
Retrospective Studies
Risk Factors
Young Adult
Grant Support
Reg. No./Substance:
0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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