Document Detail

High blood pressure and cognitive decline in mild cognitive impairment.
MedLine Citation:
PMID:  23301925     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether high blood pressure (BP) levels are associated with faster decline in specific cognitive domains.
DESIGN: Prospective longitudinal cohort.
SETTING: Uniform Data Set of the National Institutes of Health, National Institute on Aging Alzheimer's Disease Centers.
PARTICIPANTS: One thousand three hundred eighty-five participants with a diagnosis of mild cognitive impairment (MCI) and measured BP values at baseline and two annual follow-up visits.
MEASUREMENTS: Neuropsychological test scores and Clinical Dementia Rating Sum of Boxes (CDR Sum) score.
RESULTS: Participants with MCI with two or three annual occasions of high BP values (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) had significantly faster decline on neuropsychological measures of visuomotor sequencing, set shifting, and naming than those who were normotensive on all three occasions. High systolic BP values were associated as well with faster decline on the CDR Sum score.
CONCLUSION: Hypertension is associated with faster cognitive decline in persons at risk for dementia.
Felicia C Goldstein; Allan I Levey; N Kyle Steenland
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2013-01-10
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  61     ISSN:  1532-5415     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-03-07     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
Copyright Information:
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society.
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MeSH Terms
Blood Pressure / physiology*
Disease Progression
Follow-Up Studies
Hypertension / complications,  physiopathology*,  psychology
Mild Cognitive Impairment / epidemiology,  etiology,  physiopathology*
Prospective Studies
Psychiatric Status Rating Scales
United States / epidemiology
Grant Support
5 P50 AG025688/AG/NIA NIH HHS; P30 AG010130/AG/NIA NIH HHS; P50 AG025688/AG/NIA NIH HHS; U01 AG016976/AG/NIA NIH HHS; U01 AG016976/AG/NIA NIH HHS
Comment In:
J Am Geriatr Soc. 2013 Jan;61(1):155-7   [PMID:  23311556 ]

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