| High Blood Pressure Accelerates Gait Slowing in Well-Functioning Older Adults over 18-Years of Follow-Up. | |
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MedLine Citation:
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PMID: 21391929 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: To examine whether the association between hypertension and decline in gait speed is significant in well-functioning older adults and whether other health-related factors, such as brain, kidney, and heart function, can explain it. DESIGN: Longitudinal cohort study. SETTING: Cardiovascular Health Study. PARTICIPANTS: Of 2,733 potential participants with a brain magnetic resonance imaging (MRI) scan, measures of mobility and systolic blood pressure (BP), no self-reported disability in 1992 to 1994 (baseline), and with at least 1 follow-up gait speed measurement through 1997 to 1999, 643 (aged 73.6, 57% female, 15% black) who had received a second MRI in 1997 to 1999 and an additional gait speed measure in 2005 to 2006 were included. MEASUREMENTS: Mixed models with random slopes and intercepts were adjusted for age, race, and sex. Main explanatory factors included white matter hyperintensity progression, baseline cystatin-C, and left cardiac ventricular mass. Incidence of stroke and dementia, BP trajectories, and intake of antihypertensive medications during follow-up were tested as other potential explanatory factors. RESULTS: Higher systolic BP was associated with faster rate of gait speed decline in this selected group of 643 participants, and results were similar in the parent cohort (N=2,733). Participants with high BP (n=293) had a significantly faster rate of gait speed decline than those with baseline BP less than 140/90 mmHg and no history of hypertension (n=350). Rates were similar for those with history of hypertension who were uncontrolled (n=110) or controlled (n=87) at baseline and for those who were newly diagnosed (n=96) at baseline. Adjustment for explanatory factors or for other covariates (education, prevalent cardiovascular disease, physical activity, vision, mood, cognition, muscle strength, body mass index, osteoporosis) did not change the results. CONCLUSION: High BP accelerates gait slowing in well-functioning older adults over a long period of time, even for those who control their BP or develop hypertension later in life. Health-related measurements did not explain these associations. Future studies to investigate the mechanisms linking hypertension to slowing gait in older adults are warranted. |
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Authors:
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Caterina Rosano; William T Longstreth; Robert Boudreau; Christopher A Taylor; Yan Du; Lewis H Kuller; Anne B Newman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 59 ISSN: 1532-5415 ISO Abbreviation: J Am Geriatr Soc Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: United States |
Other Details:
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Languages: eng Pagination: 390-7 Citation Subset: IM |
Copyright Information:
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© 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society. |
Affiliation:
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From the *Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; and Departments of †Neurology and ‡Epidemiology, University of Washington, Seattle, Washington. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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