Document Detail


High accuracy of home-based community rapid HIV testing in rural Malawi.
MedLine Citation:
PMID:  21934554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the performance of rapid HIV antibody tests when used as part of a home-based community wide counseling and testing strategy in northern Malawi.
DESIGN: A cross-sectional population survey of HIV infection, 2007 to 2008.
METHODS: Adults aged 15 years or older in a demographic surveillance area were counseled and then offered an HIV test at their home by government-certified counselors. Two initial rapid tests (Determine and Uni-Gold) were performed on all samples and a third, tie-breaker test (SD Bioline) used to resolve discordant results. All people who wanted to know were posttest-counseled and informed of their results with referral to local clinical services if found to be HIV-positive. Laboratory quality control comprised retesting all positive and every tenth negative venous blood sample collected.
RESULTS: A total of 10,819 adults provided venous blood samples for HIV testing, of whom 7.5% (813) were HIV-positive. The accuracy of the parallel testing strategy used was high with 99.6% sensitivity, 100.0% specificity, 99.9% positive predictive value, and 99.9% negative predictive value.
CONCLUSION: Face-to-face rapid testing by health personnel with minimum training at the client's home performs well when used on a wide scale in the community setting.
Authors:
Anna M Molesworth; Richard Ndhlovu; Emmanuel Banda; Jacqueline Saul; Bagrey Ngwira; Judith R Glynn; Amelia C Crampin; Neil French
Related Documents :
1416904 - Inhibition of human immunodeficiency viral replication by tannins and related compounds.
19854224 - Early nucleoside reverse transcriptase inhibitors for the treatment of hiv: a brief his...
23491864 - Seroprevalence of transfusion transmissible infections among blood donors in western pa...
15642474 - Expression, purification, and characterization of recombinant cyanovirin-n for vaginal ...
23057274 - Prevalence and characteristics of articular manifestations in human immunodeficiency vi...
9531414 - Increasing prevalence of kingella kingae in osteoarticular infections in young children.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  55     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-09-21     Completed Date:  2011-11-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-30     Citation Subset:  IM; X    
Affiliation:
Karonga Prevention Study, Karonga District, Malawi.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
AIDS Serodiagnosis* / standards
Adolescent
Adult
Aged
Cost-Benefit Analysis
Counseling
Female
HIV Infections / diagnosis*,  epidemiology,  psychology
Home Care Services
Humans
Malawi / epidemiology
Male
Mass Screening* / methods,  standards
Middle Aged
Population Surveillance
Rural Population
Grant Support
ID/Acronym/Agency:
079828//Wellcome Trust; //Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  THE IMPACT OF TACROLIMUS ON GROWTH FACTORS IN EXPERIMENTAL PROLIFERATIVE VITREORETINOPATHY.
Next Document:  Cost-Effectiveness of Using HAART in Prevention of Mother-To-Child Transmission in the DREAM-Project...