| High (99m)Tc-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy. | |
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MedLine Citation:
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PMID: 23231421 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Amyloidotic cardiomyopathy is still a widely underdiagnosed condition that usually requires endomyocardial biopsy (EMB) for a definite diagnosis. (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) has proven highly sensitive for detecting amyloidotic cardiomyopathy due to transthyretin-related amyloid deposition. Herein we report the first description of the (99m)Tc-DPD scintigraphy profile in a patient with suspected amyloidotic cardiomyopathy and a final EMB- and genetically-proven diagnosis of familial apolipoprotein AI amyloidosis due to Leu174Ser variant. Abbreviations: AL: light-chain associated amyloidosis; ApoAI: apolipoprotein AI; ATTR: hereditary transthyretin-related amyloidosis; EMB: endomyocardial biopsy; HCM: hypertrophic cardiomyopathy; HR: heart retention; H/WB: heart/whole-body retention ratio; LV: left ventricular; SPECT: single-photon emission computed tomography; SSA: senile systemic amyloidosis; (99m)Tc-DPD: (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid; TDI: tissue Doppler imaging; TTR: transthyretin. |
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Authors:
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Candida Cristina Quarta; Laura Obici; Pier Luigi Guidalotti; Maurizio Pieroni; Simone Longhi; Stefano Perlini; Laura Verga; Giampaolo Merlini; Claudio Rapezzi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-12 |
Journal Detail:
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Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: - ISSN: 1744-2818 ISO Abbreviation: Amyloid Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433802 Medline TA: Amyloid Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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