Document Detail

High (18)F-FDG uptake by the remaining adrenal gland four months after surgery and initiation of mitotane treatment in two patients with adrenocortical carcinoma.
MedLine Citation:
PMID:  21761022     Owner:  NLM     Status:  In-Data-Review    
Two men, one 42 and the other 35 years old were both subjected to adrenalectomy for adrenocortical carcinoma (ACC). Adjuvant treatment with mitotane [o,p΄-dichloro-diphenyl-dichloroethane, (o,p΄-DDD)], was initiated following surgery. Mitotane is the only agent available at present for treatment in ACC because of a late-onset specific adrenocortical cell toxicity. Both patients underwent a (18)F-FDG-PET/CT scan, which revealed 4 months after starting treatment with mitotane significantly high (18)F-FDG uptake in the contralateral adrenal gland. Both patients underwent magnetic resonance imaging, while one had a laparotomy, because of an abcess at the site of previous adrenalectomy. No metastasis or size increase of the remaining adrenal glands were found suggesting that their hypermetabolic state could be attributed to mitotane treatment. Beside its cytotoxic delayed-effect, mitotane has an early -onset effect on steroid metabolism. In conclusion, an abnormal high (18)F-FDG uptake was observed in the contralateral adrenal gland in both our adrenalectomized ACC patients, 4 months after starting mitotane treatment, probably related to mitotane's effect on steroid metabolism, not yet fully understood.
Ioanna Mpanaka; Vassiliki D Lyra; Gregory Kaltsas; Sofia N Chatziioannou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hellenic journal of nuclear medicine     Volume:  14     ISSN:  1790-5427     ISO Abbreviation:  Hell J Nucl Med     Publication Date:    2011 May-Aug
Date Detail:
Created Date:  2011-07-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101257471     Medline TA:  Hell J Nucl Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  168-72     Citation Subset:  IM    
Department of Pathophysiology, University of Athens Medical School Attikon Hospital, 1 Rimini Str., Athens 124 64, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  (18)F-FDG PET/CT in bilateral primary adrenal T-cell lymphoma.
Next Document:  Chondroid hamartoma presenting as solitary pulmonary nodule: Results of dual time point (18)F-fluoro...