Document Detail


Hierarchical poroelasticity: movement of interstitial fluid between porosity levels in bones.
MedLine Citation:
PMID:  19657006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The governing equations for the theory of poroelastic materials with hierarchical pore space architecture and compressible constituents undergoing small deformations are developed. These equations are applied to the problem of determining the exchange of pore fluid between the vascular porosity (PV) and the lacunar-canalicular porosity (PLC) in bone tissue due to cyclic mechanical loading and blood pressure oscillations. The result is basic to the understanding of interstitial flow in bone tissue that, in turn, is basic to understanding of nutrient transport from the vasculature to the bone cells buried in the bone tissue and to the process of mechanotransduction by these cells. A formula for the volume of fluid that moves between the PLC and PV in a cyclic loading is obtained as a function of the cyclic mechanical loading and blood pressure oscillations. Formulas for the oscillating fluid pore pressure in both the PLC and the PV are obtained as functions of the two driving forces, the cyclic mechanical straining and the blood pressure, both with specified amplitude and frequency. The results of this study also suggest a PV permeability greater than 10(-9) m(2) and perhaps a little lower than 10(-8) m(2). Previous estimates of this permeability have been as small as 10(-14) m(2).
Authors:
Stephen C Cowin; Gaffar Gailani; Mohammed Benalla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Philosophical transactions. Series A, Mathematical, physical, and engineering sciences     Volume:  367     ISSN:  1364-503X     ISO Abbreviation:  Philos Trans A Math Phys Eng Sci     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-10-21     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  101133385     Medline TA:  Philos Trans A Math Phys Eng Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  3401-44     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, School of Engineering of the City College and the Graduate School of the City University of New York, New York, NY 10031, USA. scowin@earthlink.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Blood Pressure / physiology
Bone and Bones / anatomy & histology*,  blood supply,  physiology*
Elasticity
Extracellular Fluid / physiology*
Humans
Mathematics
Mechanotransduction, Cellular / physiology
Models, Biological*
Permeability

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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