Document Detail


Hierarchical organization of biological systems and the structure of adaptation in evolution and tumorigenesis.
MedLine Citation:
PMID:  9059594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biological systems are structurally organized according to patterns repeated at each hierarchical level. Complex units are composed of so-called interactors, systems that by cooperative interaction maintain the structure of the complex unit. Interactors are composed of large numbers of assemblies of complex units of a limited number of types of a lower hierarchical level. Thus, macromolecules, cells, organisms and ecological communities should be defined as complex units, and cellular organelles, organs and oligospecies populations as the interactors between those units. The similarity of organization at each level should make it possible to describe patterns of structure at one level and apply it to organization at another level. This was tested for the structural aspects of adaptation as viewed in a pathobiological context. Adaptation is then viewed as the result of stress seen at the level of the interactors or at the level of the lower complex units related to the type of stress. Subsequently, this structure of adaptation was applied to adaptation in biological evolution and tumorigenesis, which has led to the conclusion that stress is a driving force for both and that an increase in number of organisms or cells may precede heritable changes or mutations, respectively.
Authors:
H Nederbragt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of theoretical biology     Volume:  184     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-28     Completed Date:  1997-03-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Affiliation:
Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Cells*
Ecology
Models, Biological
Models, Organizational*
Neoplasms*

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