Document Detail


Hierarchical Bayesian methods for estimation of parameters in a longitudinal HIV dynamic system.
MedLine Citation:
PMID:  16918905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV dynamics studies have significantly contributed to the understanding of HIV infection and antiviral treatment strategies. But most studies are limited to short-term viral dynamics due to the difficulty of establishing a relationship of antiviral response with multiple treatment factors such as drug exposure and drug susceptibility during long-term treatment. In this article, a mechanism-based dynamic model is proposed for characterizing long-term viral dynamics with antiretroviral therapy, described by a set of nonlinear differential equations without closed-form solutions. In this model we directly incorporate drug concentration, adherence, and drug susceptibility into a function of treatment efficacy, defined as an inhibition rate of virus replication. We investigate a Bayesian approach under the framework of hierarchical Bayesian (mixed-effects) models for estimating unknown dynamic parameters. In particular, interest focuses on estimating individual dynamic parameters. The proposed methods not only help to alleviate the difficulty in parameter identifiability, but also flexibly deal with sparse and unbalanced longitudinal data from individual subjects. For illustration purposes, we present one simulation example to implement the proposed approach and apply the methodology to a data set from an AIDS clinical trial. The basic concept of the longitudinal HIV dynamic systems and the proposed methodologies are generally applicable to any other biomedical dynamic systems.
Authors:
Yangxin Huang; Dacheng Liu; Hulin Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Biometrics     Volume:  62     ISSN:  0006-341X     ISO Abbreviation:  Biometrics     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-09-28     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antiretroviral Therapy, Highly Active
Bayes Theorem*
Biometry
HIV Infections / drug therapy*,  virology*
HIV-1
Humans
Longitudinal Studies
Models, Biological
Models, Statistical
Randomized Controlled Trials as Topic / statistics & numerical data
Grant Support
ID/Acronym/Agency:
R01 AI052765/AI/NIAID NIH HHS; R01 AI055290/AI/NIAID NIH HHS; R01 AI055290/AI/NIAID NIH HHS; U01 AI27658/AI/NIAID NIH HHS
Comments/Corrections

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