Document Detail


Hidradenitis suppurativa resulting in systemic amyloid A amyloidosis: A case report and review of the literature.
MedLine Citation:
PMID:  22301039     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hidradenitis suppurativa is a chronic, inflammatory disease of the follicular epithelium that presents as tender, subcutaneous nodules in an intertriginous distribution with sinus tract formation. Most commonly, hidradenitis suppurativa results in local complications, such as scarring and infection. However, systemic complications, such as anemia and arthropathies, have also been described. Herein, we report an unusual case of systemic amyloid A secondary to hidradenitis suppurativa. We describe a 39-year-old man with a long history of recurrent, tender, erythematous nodules in the axillary and anogenital regions, resulting in abscesses, sinus tract formation, and large areas of scarring. After 21 years of cutaneous disease with concurrent elevated systemic inflammatory markers, the patient was noted to have significant proteinuria. A kidney biopsy and immunostaining revealed deposits of amyloid A. Echocardiogram and electrocardiogram showed ventricular and atrial wall thickening with an appearance consistent with cardiac amyloid deposition. Systemic amyloid A amyloidosis is a serious, but rare, complication of chronic inflammatory disorders, including hidradenitis suppurativa, with potential multi-organ involvement including renal and cardiac manifestations. Amyloid A amyloidosis should be suspected in patients with chronic inflammatory cutaneous diseases who present with renal abnormalities, especially proteinuria or the nephrotic syndrome.
Authors:
Sasha D Girouard; Rodney H Falk; Helmut G Rennke; Joseph F Merola
Related Documents :
10491929 - Management of bilaterally impacted mandibular second and third molars.
8948209 - Generalized idiopathic apical root resorption as an incidental finding in an adolescent...
10596619 - Case report: a tale of two dentures.
1055979 - Double bilateral dens invaginatus in the maxillary incisor region.
20406279 - Subconjunctival ecchymosis after extraction of maxillary molar teeth: a case report.
18059249 - Third canal in the mesial root of permanent mandibular first molars: review of the lite...
22439899 - Outcomes from ovarian hyperstimulation following the sole administration of gonadotroph...
18196469 - Brucella glomerulonephritis resulting in end-stage renal disease: a case report and a b...
19907329 - Osteochondroses: a clinical review for the pediatrician.
Publication Detail:
Type:  Journal Article     Date:  2012-01-15
Journal Detail:
Title:  Dermatology online journal     Volume:  18     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2     Citation Subset:  IM    
Affiliation:
Harvard Medical School, Boston, Massachusetts.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The affect of academic "misrepresentation" on residency match outcomes.
Next Document:  Two distinct viral infections complicating pemphigus foliaceus.