Document Detail

Hidradenitis suppurativa and concomitant pyoderma gangrenosum: a case series and literature review.
MedLine Citation:
PMID:  21079064     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are both rare inflammatory skin conditions that are associated with systemic inflammatory diseases. We performed a retrospective medical chart review of patients with an overlap of HS and PG.
OBSERVATIONS: We identified 11 cases of PG lesions presenting in patients with HS. Ten of the patients were women, and 9 were obese. All the patients developed HS lesions first, a median of 2.5 years (range, 0-15 years) preceding the appearance of PG lesions. All patients required multiple therapeutic agents because their diseases were often poorly responsive to standard therapies. Two patients received tumor necrosis factor inhibitors; 1 responded to treatment. One patient was treated with anakinra (interleukin-1 receptor antagonist) and had a 75% improvement of her lesions.
CONCLUSIONS: We have identified a group of patients who have an overlap of PG and HS. Pyoderma gangrenosum can appear at any point after the development of HS and often has a severe, refractory course. We propose that PG and HS may represent variant manifestations of cytokine dysregulation by the innate immune system with common etiology. New therapeutic agents are eagerly sought, and further investigation with regard to interleukin 1 blockade is warranted.
Jennifer L Hsiao; Richard J Antaya; Timothy Berger; Toby Maurer; Kanade Shinkai; Kieron S Leslie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of dermatology     Volume:  146     ISSN:  1538-3652     ISO Abbreviation:  Arch Dermatol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2010-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1265-70     Citation Subset:  AIM; IM    
Department of Dermatology, University of California at San Francisco, CA, USA.
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MeSH Terms
Hidradenitis Suppurativa / complications*,  pathology,  therapy
Middle Aged
Pyoderma Gangrenosum / complications*,  pathology,  therapy
Young Adult

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