| Hibernating myocardium, morphological studies on intraoperatory myocardial biopsies and on chronic ischemia experimental model. | |
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MedLine Citation:
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PMID: 18060192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hibernating myocardium represent a prolonged but potentially reversible myocardial contractile dysfunction, an incomplete adaptation caused by chronic myocardial ischemia and persisting at least until blood flow restored. The purpose of this study was to investigate the morphological changes and weather relations exist among function, metabolism and structure in left ventricular hibernating myocardium. Material and methods. Experimental study is making on 12 dogs incomplete coronary obstruction during six weeks for morphologic studies of ischemic zones. On 48 patients with coronary stenosis myocardial biopsies was effectuated during aorto-coronarian bypass graft. On 60 patients with valvular disease associated with segmental coronary atherosclerotic obstructions during surgical interventions on a effectuated repeatedly biopsies from ischemic zones. Dyskinetic ischemic areas was identified by angiography, scintigraphy, low dose dobutamine echography to identify the cells viability. On myocardial biopsies various histological, histoenzymological, immunohistochemical and ultrastructural methods were performed. RESULTS: The morphological cardiomyocytic changes can summarized: loss of myofilaments, accumulation of glycogen, small mitochondria with reversible lesions, decrease of smooth reticulum, absence of T tubules, depression of titin in puncted pattern, loss of cardiotonin, disorganization of cytoskeleton, dispersed nuclear heterochromatin, embryofetal dedifferentiation, and persistence of viability. Extracellular matrix is enlarged with early matrix protein such fibronectin, tenascin, fibroblasts. In experimental material the morphological changes present similarities with the human biopsies, but intermixed with postinfarction scar tissue. Redifferentiation of hibernanting cells end remodeling of extracellular matrix is possible after quigle revascularization through aorto-coronary bypass grafts. |
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Authors:
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D Laky; Liliana Parascan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Volume: 48 ISSN: 1220-0522 ISO Abbreviation: Rom J Morphol Embryol Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112454 Medline TA: Rom J Morphol Embryol Country: Romania |
Other Details:
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Languages: eng Pagination: 407-13 Citation Subset: IM |
Affiliation:
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Department of Pathology, Prof. dr. C. C. Iliescu Institute for Cardiovascular Diseases, Bucharest, Romania. liliana_parascan@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Dogs Humans Mitochondria, Heart / pathology Mitral Valve Insufficiency / pathology Myocardial Ischemia / pathology* Myocardial Stunning / pathology* Sarcomeres / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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