Document Detail


Hibernating myocardium in heart failure.
MedLine Citation:
PMID:  15723580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ischemic left ventricular systolic dysfunction may result from myocardial necrosis or from hypocontractile areas of viable myocardium. In some cases, recovery of contractility may occur on revascularization--this reversibly dysfunctional tissue is commonly referred to as hibernating myocardium. Observational data suggest that revascularization of patients with ischemic left ventricular systolic dysfunction and known viable myocardium provides a survival benefit over medical therapy. Identification of viable, dysfunctional myocardium may be especially worthwhile in deciding which patients with ischemic left ventricular systolic dysfunction will benefit from revascularization procedures. Randomized, prospective trials evaluating this are currently ongoing. This review will provide an overview of the complex pathophysiology of viable, dysfunctional myocardium, and will discuss outcomes after revascularization. Of the techniques used to determine the presence of hibernating myocardium, functional methods such as stress echocardiography and cardiac magnetic resonance appear more specific, but less sensitive, than the nuclear modalities, which assess perfusion and metabolic activity. Currently, the availability of all methods is variable.
Authors:
Gurbir Bhatia; Michael Sosin; John F Leahy; Derek L Connolly; Russel C Davis; Gregory Y H Lip
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  3     ISSN:  1477-9072     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-22     Completed Date:  2005-05-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-22     Citation Subset:  IM    
Affiliation:
Sandwell Hospital, Department of Cardiology, Sandwell and West Birmingham NHS Trust, West Bromwich, UK.
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MeSH Terms
Descriptor/Qualifier:
Heart Failure* / complications,  diagnosis,  pathology,  therapy
Humans
Magnetic Resonance Imaging
Myocardial Revascularization
Myocardial Stunning* / complications,  diagnosis,  pathology,  therapy
Myocardium / pathology
Tomography, Emission-Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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